Thank you SO much for your lightening fast response, Gang!
You're correct that I want to do the group analysis, and the paired t-test would be perfect if I wasn't blind to the drug and placebo sessions. The issue is that instead of calculating sessionA-sessionB or sessionB-sessionA, I need to see the Abs(sessionA-sessionB). It's completely okay if we don't know the direction of difference because we're blind. For now, we just want to see if a difference exists across drug and placebo sessions. Do you know if that's possible?
Disclaimer: I am brand new to AFNI, but have experience in FSL and Brainvoyager, please forgive me for newbie mistakes...
Lindsay