Dear Afni experts,

I have read some of afni documention on the group analysis, but it was bit difficult to know which one of the analysis track (e.g., 3dLME, 3dMEMA, or 3dMVM) would be appropriate for my case:

I have a mixed design: 1 between-ss factor (2 independent-ss groups), 1 within-ss factor (time series from TENT basis function), and 1 quantitative co-variate factor (behavioral performance). The main interest that I want to find is regional activation that shows group x covariate factor interaction (so, something similar to multiple linear regression). I can probably pick a 1 time beta-coef at peak to simply the model, so that I do not have to deal with the time series data with multiple (beta's). But it feels like an ad-hoc approach to pick a time point rather than leaving the time series as a free-variable..
Also, I have unbalanced between-ss group, which may prevent to use 3dANOVA4, I presume..?

It would be of great help to how to go about this problem..

Thank you in advance!
SJ