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AFNI and Clustering: False Positive Rates Redux

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July 26, 2016 03:33PM
Hi--

There has been a lot of discussion around a recent paper by Eklund et al. (2016) investigating false positive rates (FPRs) in the fMRI field. There were several important points raised there, in particular strong evidence that the standardly-used assumption of fMRI noise having a spatial Gaussian ACF is quite flawed. In response to this useful work, Bob has been working on some new clustering methods for AFNI-- he presented a start of this work at OHBM, and there are further descriptions and results of simulation shown here:
[biorxiv.org]

Additionally, there is discussion of the effects of the now-famous bug in 3dClustSim that was also reported in Eklund et al. (2016). A quantitative comparison is presented of the earlier "buggy" version of 3dClustSim and the fixed version (that has been in AFNI since May, 2015) using the same simulations. Importantly, the effects of the bug on FPRs was quite small-- see the linked draft for more details.

And there are even *other* interesting points discussed, including implications of all the above results on experimental design and parameter choices during analysis. Enjoy!

--pt
Subject Author Posted

AFNI and Clustering: False Positive Rates Redux

ptaylor July 26, 2016 03:33PM

Re: AFNI and Clustering: False Positive Rates Redux

storrisi July 29, 2016 02:49PM

Re: AFNI and Clustering: False Positive Rates Redux

Nathaniel Harnett August 03, 2016 10:38AM



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