Dear rick,

Thanks for your immediately reply, I get the difference between 3drefit and 3dresample, but get confused by "leaves the brain in the same location in space, but changes it on disk", could you explain further?

As I known, there are four attributes in afni related to orientation:
1.the -orientation option showed by 3dinfo
2.R-L extent ... option showed by 3dinfo
3.the upper left corner of afni GUI, with RAI and SPM LPI option
4.the actual orientation they are stored

To my understanding, the -orientation in the header is the actual orientation they are stored, while R-L extent .... is the same preference as the upper left corner orientation option in afni GUI, is this right?

if not, what's the difference of these four attributes? could you show some details?

Best wishes,
Peng