Hello,
I am performing a t-test to see if my effect is lateralized as hypothesized. I do this by comparing the original contrast (Original) with the contrast in the symmetric voxel in the other hemisphere (Flipped). I used ttest++ with the ClustSim option.
I already ran a 3dClustSim simulation on averaged ACF parameteres, for the group level effect. The threshold in this table is VERY different from the ttest++ ClustSim output. Which of these is better to rely on?
I have an intuition that 3dClustSim is not the right thing to use when I compare two voxels on the same brain, but I am not sure. Any response is appreciated!
Thank you.

** EDIT **
In the aformentioned ttest++ with ClustSim, I could show that one stimulus has a lateralized effect and the other does not. I ran a second analysis, 2-by-2 ANOVA with 3dANOVA3, to identify clusteres significant for an interaction between Laterality (original/flipped) and the type of stimulus.
As I noted, the thresholds of ClustSim and 3dClustSim are far from being the same. But for 3dANOVA3 I don't have any other option. However, I am not sure that 3dClustSim is the right thing to do when comparing original vs. flipped - the ACF function assumes that a voxel is being compared to itself, as far as I understand... I would appreciate any advice.



Edited 1 time(s). Last edit at 01/29/2020 04:06AM by Galit.