The statistical evidence is intrinsically continuous, so why would we have to stick to a specific cutoff value? The sphericity assumption could be violated, leading to inflated F-statistics. On the other hand, the false assumption of no common information shared across the brain results in inefficient modeling with the mass univariate approach, and excessively penalizes the statistical evidence. In addition, I would not consider a cluster threshold as an imprimatur for statistical rigor, but something loosely suggestive. Instead, I would feel much more convincing with the following than the meticulous focus on the threshold. Show the hard evidence of HDR: regardless of the cluster size, demonstrate the estimated response curve at the region with an HDR signature shape.

Gang



Edited 1 time(s). Last edit at 05/19/2020 07:28AM by Gang.