Thanks - I had forgotten about the partial coverage option. Sadly that didn't seem to work, even with trying out the different cost function options. The thing that gets me is that it looks decently aligned in original space; it's only after the Talairach transform gets applied that things seem to go awry. I've attached a screenshot of the aligned EPI and anat in original space (the final results look about the same as the screenshot in the earlier post).
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Screen Shot 2021-09-15 at 10.33.33 AM.png
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