Thank you Dr. Gang (as always). I will have to do some more reading on beta series to get my head around the approach.
One thought our team had in response to your concerns was running Seed-to-whole brain FC correlations analysis using only non-overlapping/interleaved portions of our condition of interest for the seed signal to avoid the modeling/deconvolution issue. Would there be any conceptual issues to looking for correlations of this partial signal (e.g. without many of the HDR tails)?
~Dane