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¥Quick outline of procedure:
1.On the main AFNI control panel, set the anatomical underlay dataset (with [Switch UnderLay]) to be what you want to draw on -- usually a SPGR or MP-RAGE type of dataset
åi.e., the anatomical underlay will serve as our guide or template for drawing the ROI mask
2.Start the Draw Dataset plugin (this is our ROI-creating plugin):
å [Define Datamode] ¨ [Plugins] ¨ [Draw Dataset]
3.Create an all zero anatomical overlay dataset with the Draw Dataset plugin.  This is the beginning of our ROI mask.  At this point, the anatomical overlay is empty - i.e., all the voxel values are zero
åThis anatomical overlay must have the same geometry as the anatomical underlay, i.e., it has the same voxel size as the underlay, the same xyz-grid spacing, etcÉ, since drawing/editing is done on a voxel-by-voxel basis
íThink of the anat overlay as a blank piece of tracing paper that is the same size as the template underneath. The blank overlay will be used to trace portions of the underlay.  Voxels inside the traced portion will make up the ROI mask.  Values outside the traced region are irrelevant (zeros)
åNote: You could also edit an already-existing ROI mask (that you created earlier) at this step