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4.To view and begin drawing an ROI mask (or several ROIs) on this blank anatomical overlay dataset, go to the main AFNI interface and [Switch Overlay] to be the empty anatomical dataset you will be editing.  Also turn the overlay ON with [See OverLay]
5.Start drawing the ROI mask into this blank anatomical overlay dataset.  Voxels inside the ROI mask will receive a non-zero value (you decide what value to give them).  Values outside the ROI mask will remain zero 
åBe sure to save the results by pressing [Save], [SaveAs] or [DONE] in the ROI plugin GUI ([Quit] will exit the ROI plugin without saving your work)
6.Convert the anatomical-resolution ROI dataset into a dataset at the resolution of the functional (statistical) datasets you want to analyze with the ROI
åNote: The ROI and functional datasets may already be at the same resolution, if you are operating in +tlrc coordinates
åResolution conversion of masks is done with program 3dfractionize
7.Use programs 3dmaskave, 3dmaskdump, and 3dROIstats to extract ROI-based information about functional datasets
åAlso can use the ROI Average plugin to extract interactively the average of a dataset over a ROI