Hi,

I was wondering when should despiking be performed when analyzing resting-state data. Should it be done at the end of preprocessing or right at the beginning? I also wonder how 3dDespike relates to the wavelet algorithm proposed by Patel et. al (2014). In their paper they say "This is in contrast to the Time Despike, and other sinusoidal curve fitting or tanh functions (such as AFNI's 3dDespike) for despiking time series, which will only be effective at isolating high frequency events, and will interpolate spikes with a value calculated form the surrounding time points or from a fitted curve. Additionally, these interpolating algorithms may not always correctly identify movement artifacts...". Are these limitations still true in the current version of 3dDespike?
Thanks.