00001 #ifndef _NIFTI_HEADER_ 00002 #define _NIFTI_HEADER_ 00003 00004 /***************************************************************************** 00005 ** This file defines the "NIFTI-1" header format. ** 00006 ** It is derived from 2 meetings at the NIH (31 Mar 2003 and ** 00007 ** 02 Sep 2003) of the Data Format Working Group (DFWG), ** 00008 ** chartered by the NIfTI (Neuroimaging Informatics Technology ** 00009 ** Initiative) at the National Institutes of Health (NIH). ** 00010 **--------------------------------------------------------------** 00011 ** Neither the National Institutes of Health (NIH), the DFWG, ** 00012 ** nor any of the members or employees of these institutions ** 00013 ** imply any warranty of usefulness of this material for any ** 00014 ** purpose, and do not assume any liability for damages, ** 00015 ** incidental or otherwise, caused by any use of this document. ** 00016 ** If these conditions are not acceptable, do not use this! ** 00017 **--------------------------------------------------------------** 00018 ** Author: Robert W Cox (NIMH, Bethesda) ** 00019 ** Advisors: John Ashburner (FIL, London), ** 00020 ** Stephen Smith (FMRIB, Oxford), ** 00021 ** Mark Jenkinson (FMRIB, Oxford) ** 00022 ******************************************************************************/ 00023 00024 /*---------------------------------------------------------------------------*/ 00025 /* Note that the ANALYZE 7.5 file header (dbh.h) is 00026 (c) Copyright 1986-1995 00027 Biomedical Imaging Resource 00028 Mayo Foundation 00029 Incorporation of components of dbh.h are by permission of the 00030 Mayo Foundation. 00031 00032 Changes from the ANALYZE 7.5 file header in this file are released to the 00033 public domain, including the functional comments and any amusing asides. 00034 -----------------------------------------------------------------------------*/ 00035 00036 /*---------------------------------------------------------------------------*/ 00037 /*! INTRODUCTION TO NIFTI-1: 00038 ------------------------ 00039 The twin (and somewhat conflicting) goals of this modified ANALYZE 7.5 00040 format are: 00041 (a) To add information to the header that will be useful for functional 00042 neuroimaging data analysis and display. These additions include: 00043 - More basic data types. 00044 - Two affine transformations to specify voxel coordinates. 00045 - "Intent" codes and parameters to describe the meaning of the data. 00046 - Affine scaling of the stored data values to their "true" values. 00047 - Optional storage of the header and image data in one file (.nii). 00048 (b) To maintain compatibility with non-NIFTI-aware ANALYZE 7.5 compatible 00049 software (i.e., such a program should be able to do something useful 00050 with a NIFTI-1 dataset -- at least, with one stored in a traditional 00051 .img/.hdr file pair). 00052 00053 Most of the unused fields in the ANALYZE 7.5 header have been taken, 00054 and some of the lesser-used fields have been co-opted for other purposes. 00055 Notably, most of the data_history substructure has been co-opted for 00056 other purposes, since the ANALYZE 7.5 format describes this substructure 00057 as "not required". 00058 00059 NIFTI-1 FLAG (MAGIC STRINGS): 00060 ---------------------------- 00061 To flag such a struct as being conformant to the NIFTI-1 spec, the last 4 00062 bytes of the header must be either the C String "ni1" or "n+1"; 00063 in hexadecimal, the 4 bytes 00064 6E 69 31 00 or 6E 2B 31 00 00065 (in any future version of this format, the '1' will be upgraded to '2', 00066 etc.). Normally, such a "magic number" or flag goes at the start of the 00067 file, but trying to avoid clobbering widely-used ANALYZE 7.5 fields led to 00068 putting this marker last. However, recall that "the last shall be first" 00069 (Matthew 20:16). 00070 00071 If a NIFTI-aware program reads a header file that is NOT marked with a 00072 NIFTI magic string, then it should treat the header as an ANALYZE 7.5 00073 structure. 00074 00075 NIFTI-1 FILE STORAGE: 00076 -------------------- 00077 "ni1" means that the image data is stored in the ".img" file corresponding 00078 to the header file (starting at file offset 0). 00079 00080 "n+1" means that the image data is stored in the same file as the header 00081 information. We recommend that the combined header+data filename suffix 00082 be ".nii". When the dataset is stored in one file, the first byte of image 00083 data is stored at byte location (int)vox_offset in this combined file. 00084 The minimum allowed value of vox_offset is 352; for compatibility with 00085 some software, vox_offset should be an integral multiple of 16. 00086 00087 GRACE UNDER FIRE: 00088 ---------------- 00089 Most NIFTI-aware programs will only be able to handle a subset of the full 00090 range of datasets possible with this format. All NIFTI-aware programs 00091 should take care to check if an input dataset conforms to the program's 00092 needs and expectations (e.g., check datatype, intent_code, etc.). If the 00093 input dataset can't be handled by the program, the program should fail 00094 gracefully (e.g., print a useful warning; not crash). 00095 00096 SAMPLE CODES: 00097 ------------ 00098 The associated files nifti1_io.h and nifti1_io.c provide a sample 00099 implementation in C of a set of functions to read, write, and manipulate 00100 NIFTI-1 files. The file nifti1_test.c is a sample program that uses 00101 the nifti1_io.c functions. 00102 -----------------------------------------------------------------------------*/ 00103 00104 /*---------------------------------------------------------------------------*/ 00105 /* HEADER STRUCT DECLARATION: 00106 ------------------------- 00107 In the comments below for each field, only NIFTI-1 specific requirements 00108 or changes from the ANALYZE 7.5 format are described. For convenience, 00109 the 348 byte header is described as a single struct, rather than as the 00110 ANALYZE 7.5 group of 3 substructs. 00111 00112 Further comments about the interpretation of various elements of this 00113 header are after the data type definition itself. Fields that are 00114 marked as ++UNUSED++ have no particular interpretation in this standard. 00115 (Also see the UNUSED FIELDS comment section, far below.) 00116 00117 The presumption below is that the various C types have particular sizes: 00118 sizeof(int) = sizeof(float) = 4 ; sizeof(short) = 2 00119 -----------------------------------------------------------------------------*/ 00120 00121 /*=================*/ 00122 #ifdef __cplusplus 00123 extern "C" { 00124 #endif 00125 /*=================*/ 00126 /*************************/ /************************/ 00127 struct nifti_1_header { /* NIFTI-1 usage */ /* ANALYZE 7.5 field(s) */ 00128 /*************************/ /************************/ 00129 00130 /*--- was header_key substruct ---*/ 00131 int sizeof_hdr; /*!< MUST be 348 */ /* int sizeof_hdr; */ 00132 char data_type[10]; /*!< ++UNUSED++ */ /* char data_type[10]; */ 00133 char db_name[18]; /*!< ++UNUSED++ */ /* char db_name[18]; */ 00134 int extents; /*!< ++UNUSED++ */ /* int extents; */ 00135 short session_error; /*!< ++UNUSED++ */ /* short session_error; */ 00136 char regular; /*!< ++UNUSED++ */ /* char regular; */ 00137 char dim_info; /*!< MRI slice ordering. */ /* char hkey_un0; */ 00138 00139 /*--- was image_dimension substruct ---*/ 00140 short dim[8]; /*!< Data array dimensions.*/ /* short dim[8]; */ 00141 float intent_p1 ; /*!< 1st intent parameter. */ /* short unused8; */ 00142 /* short unused9; */ 00143 float intent_p2 ; /*!< 2nd intent parameter. */ /* short unused10; */ 00144 /* short unused11; */ 00145 float intent_p3 ; /*!< 3rd intent parameter. */ /* short unused12; */ 00146 /* short unused13; */ 00147 short intent_code ; /*!< NIFTI_INTENT_* code. */ /* short unused14; */ 00148 short datatype; /*!< Defines data type! */ /* short datatype; */ 00149 short bitpix; /*!< Number bits/voxel. */ /* short bitpix; */ 00150 short slice_start; /*!< First slice index. */ /* short dim_un0; */ 00151 float pixdim[8]; /*!< Grid spacings. */ /* float pixdim[8]; */ 00152 float vox_offset; /*!< Offset into .nii file */ /* float vox_offset; */ 00153 float scl_slope ; /*!< Data scaling: slope. */ /* float funused1; */ 00154 float scl_inter ; /*!< Data scaling: offset. */ /* float funused2; */ 00155 short slice_end; /*!< Last slice index. */ /* float funused3; */ 00156 char slice_code ; /*!< Slice timing order. */ 00157 char xyzt_units ; /*!< Units of pixdim[1..4] */ 00158 float cal_max; /*!< Max display intensity */ /* float cal_max; */ 00159 float cal_min; /*!< Min display intensity */ /* float cal_min; */ 00160 float slice_duration;/*!< Time for 1 slice. */ /* float compressed; */ 00161 float toffset; /*!< Time axis shift. */ /* float verified; */ 00162 int glmax; /*!< ++UNUSED++ */ /* int glmax; */ 00163 int glmin; /*!< ++UNUSED++ */ /* int glmin; */ 00164 00165 /*--- was data_history substruct ---*/ 00166 char descrip[80]; /*!< any text you like. */ /* char descrip[80]; */ 00167 char aux_file[24]; /*!< auxiliary filename. */ /* char aux_file[24]; */ 00168 00169 short qform_code ; /*!< NIFTI_XFORM_* code. */ /*-- all ANALYZE 7.5 ---*/ 00170 short sform_code ; /*!< NIFTI_XFORM_* code. */ /* fields below here */ 00171 /* are replaced */ 00172 float quatern_b ; /*!< Quaternion b param. */ 00173 float quatern_c ; /*!< Quaternion c param. */ 00174 float quatern_d ; /*!< Quaternion d param. */ 00175 float qoffset_x ; /*!< Quaternion x shift. */ 00176 float qoffset_y ; /*!< Quaternion y shift. */ 00177 float qoffset_z ; /*!< Quaternion z shift. */ 00178 00179 float srow_x[4] ; /*!< 1st row affine transform. */ 00180 float srow_y[4] ; /*!< 2nd row affine transform. */ 00181 float srow_z[4] ; /*!< 3rd row affine transform. */ 00182 00183 char intent_name[16];/*!< 'name' or meaning of data. */ 00184 00185 char magic[4] ; /*!< MUST be "ni1\0" or "n+1\0". */ 00186 00187 } ; /**** 348 bytes total ****/ 00188 00189 typedef struct nifti_1_header nifti_1_header ; 00190 00191 /*---------------------------------------------------------------------------*/ 00192 /* HEADER EXTENSIONS: 00193 ----------------- 00194 After the end of the 348 byte header (e.g., after the magic field), 00195 the next 4 bytes are a char array field named "extension". By default, 00196 all 4 bytes of this array should be set to zero. In a .nii file, these 00197 4 bytes will always be present, since the earliest start point for 00198 the image data is byte #352. In a separate .hdr file, these bytes may 00199 or may not be present. If not present (i.e., if the length of the .hdr 00200 file is 348 bytes), then a NIfTI-1 compliant program should use the 00201 default value of extension={0,0,0,0}. The first byte (extension[0]) 00202 is the only value of this array that is specified at present. The other 00203 3 bytes are reserved for future use. 00204 00205 If extension[0] is nonzero, it indicates that extended header information 00206 is present in the bytes following the extension array. In a .nii file, 00207 this extended header data is before the image data (and vox_offset 00208 must be set correctly to allow for this). In a .hdr file, this extended 00209 data follows extension and proceeds (potentially) to the end of the file. 00210 00211 The format of extended header data is weakly specified. Each extension 00212 must be an integer multiple of 16 bytes long. The first 8 bytes of each 00213 extension comprise 2 integers: 00214 int esize , ecode ; 00215 These values may need to be byte-swapped, as indicated by dim[0] for 00216 the rest of the header. 00217 * esize is the number of bytes that form the extended header data 00218 + esize must be a positive integral multiple of 16 00219 + this length includes the 8 bytes of esize and ecode themselves 00220 * ecode is a non-negative integer that indicates the format of the 00221 extended header data that follows 00222 + different ecode values are assigned to different developer groups 00223 + at present, the "registered" values for code are 00224 = 0 = unknown private format (not recommended!) 00225 = 2 = DICOM format (i.e., attribute tags and values) 00226 = 4 = AFNI group (i.e., ASCII XML-ish elements) 00227 In the interests of interoperability (a primary rationale for NIfTI), 00228 groups developing software that uses this extension mechanism are 00229 encouraged to document and publicize the format of their extensions. 00230 To this end, the NIfTI DFWG will assign even numbered codes upon request 00231 to groups submitting at least rudimentary documentation for the format 00232 of their extension; at present, the contact is mailto:rwcox@nih.gov. 00233 The assigned codes and documentation will be posted on the NIfTI 00234 website. All odd values of ecode (and 0) will remain unassigned; 00235 at least, until the even ones are used up, when we get to 2,147,483,646. 00236 00237 Note that the other contents of the extended header data section are 00238 totally unspecified by the NIfTI-1 standard. In particular, if binary 00239 data is stored in such a section, its byte order is not necessarily 00240 the same as that given by examining dim[0]; it is incumbent on the 00241 programs dealing with such data to determine the byte order of binary 00242 extended header data. 00243 00244 Multiple extended header sections are allowed, each starting with an 00245 esize,ecode value pair. The first esize value, as described above, 00246 is at bytes #352-355 in the .hdr or .nii file (files start at byte #0). 00247 If this value is positive, then the second (esize2) will be found 00248 starting at byte #352+esize1 , the third (esize3) at byte #352+esize1+esize2, 00249 et cetera. Of course, in a .nii file, the value of vox_offset must 00250 be compatible with these extensions. If a malformed file indicates 00251 that an extended header data section would run past vox_offset, then 00252 the entire extended header section should be ignored. In a .hdr file, 00253 if an extended header data section would run past the end-of-file, 00254 that extended header data should also be ignored. 00255 00256 With the above scheme, a program can successively examine the esize 00257 and ecode values, and skip over each extended header section if the 00258 program doesn't know how to interpret the data within. Of course, any 00259 program can simply ignore all extended header sections simply by jumping 00260 straight to the image data using vox_offset. 00261 -----------------------------------------------------------------------------*/ 00262 00263 struct nifti1_extender { char extension[4] ; } ; 00264 typedef struct nifti1_extender nifti1_extender ; 00265 00266 struct nifti1_extension { 00267 int esize , ecode ; 00268 char *edata ; 00269 } ; 00270 typedef struct nifti1_extension nifti1_extension ; 00271 00272 /*---------------------------------------------------------------------------*/ 00273 /* DATA DIMENSIONALITY (as in ANALYZE 7.5): 00274 --------------------------------------- 00275 dim[0] = number of dimensions; 00276 - if dim[0] is outside range 1..7, then the header information 00277 needs to be byte swapped appropriately 00278 - ANALYZE supports dim[0] up to 7, but NIFTI-1 reserves 00279 dimensions 1,2,3 for space (x,y,z), 4 for time (t), and 00280 5,6,7 for anything else needed. 00281 00282 dim[i] = length of dimension #i, for i=1..dim[0] (must be positive) 00283 - also see the discussion of intent_code, far below 00284 00285 pixdim[i] = voxel width along dimension #i, i=1..dim[0] (positive) 00286 - cf. ORIENTATION section below for use of pixdim[0] 00287 - the units of pixdim can be specified with the xyzt_units 00288 field (also described far below). 00289 00290 Number of bits per voxel value is in bitpix, which MUST correspond with 00291 the datatype field. The total number of bytes in the image data is 00292 dim[1] * ... * dim[dim[0]] * bitpix / 8 00293 00294 In NIFTI-1 files, dimensions 1,2,3 are for space, dimension 4 is for time, 00295 and dimension 5 is for storing multiple values at each spatiotemporal 00296 voxel. Some examples: 00297 - A typical whole-brain FMRI experiment's time series: 00298 - dim[0] = 4 00299 - dim[1] = 64 pixdim[1] = 3.75 xyzt_units = NIFTI_UNITS_MM 00300 - dim[2] = 64 pixdim[2] = 3.75 | NIFTI_UNITS_SEC 00301 - dim[3] = 20 pixdim[3] = 5.0 00302 - dim[4] = 120 pixdim[4] = 2.0 00303 - A typical T1-weighted anatomical volume: 00304 - dim[0] = 3 00305 - dim[1] = 256 pixdim[1] = 1.0 xyzt_units = NIFTI_UNITS_MM 00306 - dim[2] = 256 pixdim[2] = 1.0 00307 - dim[3] = 128 pixdim[3] = 1.1 00308 - A single slice EPI time series: 00309 - dim[0] = 4 00310 - dim[1] = 64 pixdim[1] = 3.75 xyzt_units = NIFTI_UNITS_MM 00311 - dim[2] = 64 pixdim[2] = 3.75 | NIFTI_UNITS_SEC 00312 - dim[3] = 1 pixdim[3] = 5.0 00313 - dim[4] = 1200 pixdim[4] = 0.2 00314 - A 3-vector stored at each point in a 3D volume: 00315 - dim[0] = 5 00316 - dim[1] = 256 pixdim[1] = 1.0 xyzt_units = NIFTI_UNITS_MM 00317 - dim[2] = 256 pixdim[2] = 1.0 00318 - dim[3] = 128 pixdim[3] = 1.1 00319 - dim[4] = 1 pixdim[4] = 0.0 00320 - dim[5] = 3 intent_code = NIFTI_INTENT_VECTOR 00321 - A single time series with a 3x3 matrix at each point: 00322 - dim[0] = 5 00323 - dim[1] = 1 xyzt_units = NIFTI_UNITS_SEC 00324 - dim[2] = 1 00325 - dim[3] = 1 00326 - dim[4] = 1200 pixdim[4] = 0.2 00327 - dim[5] = 9 intent_code = NIFTI_INTENT_GENMATRIX 00328 - intent_p1 = intent_p2 = 3.0 (indicates matrix dimensions) 00329 -----------------------------------------------------------------------------*/ 00330 00331 /*---------------------------------------------------------------------------*/ 00332 /* DATA STORAGE: 00333 ------------ 00334 If the magic field is "n+1", then the voxel data is stored in the 00335 same file as the header. In this case, the voxel data starts at offset 00336 (int)vox_offset into the header file. Thus, vox_offset=352.0 means that 00337 the data starts immediately after the NIFTI-1 header. If vox_offset is 00338 greater than 352, the NIFTI-1 format does not say much about the 00339 contents of the dataset file between the end of the header and the 00340 start of the data. 00341 00342 FILES: 00343 ----- 00344 If the magic field is "ni1", then the voxel data is stored in the 00345 associated ".img" file, starting at offset 0 (i.e., vox_offset is not 00346 used in this case, and should be set to 0.0). 00347 00348 When storing NIFTI-1 datasets in pairs of files, it is customary to name 00349 the files in the pattern "name.hdr" and "name.img", as in ANALYZE 7.5. 00350 When storing in a single file ("n+1"), the file name should be in 00351 the form "name.nii" (the ".nft" and ".nif" suffixes are already taken; 00352 cf. http://www.icdatamaster.com/n.html ). 00353 00354 BYTE ORDERING: 00355 ------------- 00356 The byte order of the data arrays is presumed to be the same as the byte 00357 order of the header (which is determined by examining dim[0]). 00358 00359 Floating point types are presumed to be stored in IEEE-754 format. 00360 -----------------------------------------------------------------------------*/ 00361 00362 /*---------------------------------------------------------------------------*/ 00363 /* DETAILS ABOUT vox_offset: 00364 ------------------------ 00365 In a .nii file, the vox_offset field value is interpreted as the start 00366 location of the image data bytes in that file. In a .hdr/.img file pair, 00367 the vox_offset field value is the start location of the image data 00368 bytes in the .img file. 00369 * If vox_offset is less than 352 in a .nii file, it is equivalent 00370 to 352 (i.e., image data never starts before byte #352 in a .nii file). 00371 * The default value for vox_offset in a .nii file is 352. 00372 * In a .hdr file, the default value for vox_offset is 0. 00373 * vox_offset should be an integer multiple of 16; otherwise, some 00374 programs may not work properly (e.g., SPM). This is to allow 00375 memory-mapped input to be properly byte-aligned. 00376 Note that since vox_offset is an IEEE-754 32 bit float (for compatibility 00377 with the ANALYZE-7.5 format), it effectively has a 24 bit mantissa. All 00378 integers from 0 to 2^24 can be represented exactly in this format, but not 00379 all larger integers are exactly storable as IEEE-754 32 bit floats. However, 00380 unless you plan to have vox_offset be potentially larger than 16 MB, this 00381 should not be an issue. (Actually, any integral multiple of 16 up to 2^27 00382 can be represented exactly in this format, which allows for up to 128 MB 00383 of random information before the image data. If that isn't enough, then 00384 perhaps this format isn't right for you.) 00385 00386 In a .img file (i.e., image data stored separately from the NIfTI-1 00387 header), data bytes between #0 and #vox_offset-1 (inclusive) are completely 00388 undefined and unregulated by the NIfTI-1 standard. One potential use of 00389 having vox_offset > 0 in the .hdr/.img file pair storage method is to make 00390 the .img file be a copy of (or link to) a pre-existing image file in some 00391 other format, such as DICOM; then vox_offset would be set to the offset of 00392 the image data in this file. (It may not be possible to follow the 00393 "multiple-of-16 rule" with an arbitrary external file; using the NIfTI-1 00394 format in such a case may lead to a file that is incompatible with software 00395 that relies on vox_offset being a multiple of 16.) 00396 00397 In a .nii file, data bytes between #348 and #vox_offset-1 (inclusive) may 00398 be used to store user-defined extra information; similarly, in a .hdr file, 00399 any data bytes after byte #347 are available for user-defined extra 00400 information. The (very weak) regulation of this extra header data is 00401 described elsewhere. 00402 -----------------------------------------------------------------------------*/ 00403 00404 /*---------------------------------------------------------------------------*/ 00405 /* DATA SCALING: 00406 ------------ 00407 If the scl_slope field is nonzero, then each voxel value in the dataset 00408 should be scaled as 00409 y = scl_slope * x + scl_inter 00410 where x = voxel value stored 00411 y = "true" voxel value 00412 Normally, we would expect this scaling to be used to store "true" floating 00413 values in a smaller integer datatype, but that is not required. That is, 00414 it is legal to use scaling even if the datatype is a float type (crazy, 00415 perhaps, but legal). 00416 - However, the scaling is to be ignored if datatype is DT_RGB24. 00417 - If datatype is a complex type, then the scaling is to be 00418 applied to both the real and imaginary parts. 00419 00420 The cal_min and cal_max fields (if nonzero) are used for mapping (possibly 00421 scaled) dataset values to display colors: 00422 - Minimum display intensity (black) corresponds to dataset value cal_min. 00423 - Maximum display intensity (white) corresponds to dataset value cal_max. 00424 - Dataset values below cal_min should display as black also, and values 00425 above cal_max as white. 00426 - Colors "black" and "white", of course, may refer to any scalar display 00427 scheme (e.g., a color lookup table specified via aux_file). 00428 - cal_min and cal_max only make sense when applied to scalar-valued 00429 datasets (i.e., dim[0] < 5 or dim[5] = 1). 00430 -----------------------------------------------------------------------------*/ 00431 00432 /*---------------------------------------------------------------------------*/ 00433 /* TYPE OF DATA (acceptable values for datatype field): 00434 --------------------------------------------------- 00435 Values of datatype smaller than 256 are ANALYZE 7.5 compatible. 00436 Larger values are NIFTI-1 additions. These are all multiples of 256, so 00437 that no bits below position 8 are set in datatype. But there is no need 00438 to use only powers-of-2, as the original ANALYZE 7.5 datatype codes do. 00439 00440 The additional codes are intended to include a complete list of basic 00441 scalar types, including signed and unsigned integers from 8 to 64 bits, 00442 floats from 32 to 128 bits, and complex (float pairs) from 64 to 256 bits. 00443 00444 Note that most programs will support only a few of these datatypes! 00445 A NIFTI-1 program should fail gracefully (e.g., print a warning message) 00446 when it encounters a dataset with a type it doesn't like. 00447 -----------------------------------------------------------------------------*/ 00448 00449 #undef DT_UNKNOWN /* defined in dirent.h on some Unix systems */ 00450 00451 /*--- the original ANALYZE 7.5 type codes ---*/ 00452 #define DT_NONE 0 00453 #define DT_UNKNOWN 0 /* what it says, dude */ 00454 #define DT_BINARY 1 /* binary (1 bit/voxel) */ 00455 #define DT_UNSIGNED_CHAR 2 /* unsigned char (8 bits/voxel) */ 00456 #define DT_SIGNED_SHORT 4 /* signed short (16 bits/voxel) */ 00457 #define DT_SIGNED_INT 8 /* signed int (32 bits/voxel) */ 00458 #define DT_FLOAT 16 /* float (32 bits/voxel) */ 00459 #define DT_COMPLEX 32 /* complex (64 bits/voxel) */ 00460 #define DT_DOUBLE 64 /* double (64 bits/voxel) */ 00461 #define DT_RGB 128 /* RGB triple (24 bits/voxel) */ 00462 #define DT_ALL 255 /* not very useful (?) */ 00463 00464 /*----- another set of names for the same ---*/ 00465 #define DT_UINT8 2 00466 #define DT_INT16 4 00467 #define DT_INT32 8 00468 #define DT_FLOAT32 16 00469 #define DT_COMPLEX64 32 00470 #define DT_FLOAT64 64 00471 #define DT_RGB24 128 00472 00473 /*------------------- new codes for NIFTI ---*/ 00474 #define DT_INT8 256 /* signed char (8 bits) */ 00475 #define DT_UINT16 512 /* unsigned short (16 bits) */ 00476 #define DT_UINT32 768 /* unsigned int (32 bits) */ 00477 #define DT_INT64 1024 /* long long (64 bits) */ 00478 #define DT_UINT64 1280 /* unsigned long long (64 bits) */ 00479 #define DT_FLOAT128 1536 /* long double (128 bits) */ 00480 #define DT_COMPLEX128 1792 /* double pair (128 bits) */ 00481 #define DT_COMPLEX256 2048 /* long double pair (256 bits) */ 00482 00483 /*------- aliases for all the above codes ---*/ 00484 00485 /*! unsigned char. */ 00486 #define NIFTI_TYPE_UINT8 2 00487 /*! signed short. */ 00488 #define NIFTI_TYPE_INT16 4 00489 /*! signed int. */ 00490 #define NIFTI_TYPE_INT32 8 00491 /*! 32 bit float. */ 00492 #define NIFTI_TYPE_FLOAT32 16 00493 /*! 64 bit complex = 2 32 bit floats. */ 00494 #define NIFTI_TYPE_COMPLEX64 32 00495 /*! 64 bit float = double. */ 00496 #define NIFTI_TYPE_FLOAT64 64 00497 /*! 3 8 bit bytes. */ 00498 #define NIFTI_TYPE_RGB24 128 00499 /*! signed char. */ 00500 #define NIFTI_TYPE_INT8 256 00501 /*! unsigned short. */ 00502 #define NIFTI_TYPE_UINT16 512 00503 /*! unsigned int. */ 00504 #define NIFTI_TYPE_UINT32 768 00505 /*! signed long long. */ 00506 #define NIFTI_TYPE_INT64 1024 00507 /*! unsigned long long. */ 00508 #define NIFTI_TYPE_UINT64 1280 00509 /*! 128 bit float = long double. */ 00510 #define NIFTI_TYPE_FLOAT128 1536 00511 /*! 128 bit complex = 2 64 bit floats. */ 00512 #define NIFTI_TYPE_COMPLEX128 1792 00513 /*! 256 bit complex = 2 128 bit floats */ 00514 #define NIFTI_TYPE_COMPLEX256 2048 00515 00516 /*-------- sample typedefs for complicated types ---*/ 00517 #if 0 00518 typedef struct { float r,i; } complex_float ; 00519 typedef struct { double r,i; } complex_double ; 00520 typedef struct { long double r,i; } complex_longdouble ; 00521 typedef struct { unsigned char r,g,b; } rgb_byte ; 00522 #endif 00523 00524 /*---------------------------------------------------------------------------*/ 00525 /* INTERPRETATION OF VOXEL DATA: 00526 ---------------------------- 00527 The intent_code field can be used to indicate that the voxel data has 00528 some particular meaning. In particular, a large number of codes is 00529 given to indicate that the the voxel data should be interpreted as 00530 being drawn from a given probability distribution. 00531 00532 VECTOR-VALUED DATASETS: 00533 ---------------------- 00534 The 5th dimension of the dataset, if present (i.e., dim[0]=5 and 00535 dim[5] > 1), contains multiple values (e.g., a vector) to be stored 00536 at each spatiotemporal location. For example, the header values 00537 - dim[0] = 5 00538 - dim[1] = 64 00539 - dim[2] = 64 00540 - dim[3] = 20 00541 - dim[4] = 1 (indicates no time axis) 00542 - dim[5] = 3 00543 - datatype = DT_FLOAT 00544 - intent_code = NIFTI_INTENT_VECTOR 00545 mean that this dataset should be interpreted as a 3D volume (64x64x20), 00546 with a 3-vector of floats defined at each point in the 3D grid. 00547 00548 A program reading a dataset with a 5th dimension may want to reformat 00549 the image data to store each voxels' set of values together in a struct 00550 or array. This programming detail, however, is beyond the scope of the 00551 NIFTI-1 file specification! Uses of dimensions 6 and 7 are also not 00552 specified here. 00553 00554 STATISTICAL PARAMETRIC DATASETS (i.e., SPMs): 00555 -------------------------------------------- 00556 Values of intent_code from NIFTI_FIRST_STATCODE to NIFTI_LAST_STATCODE 00557 (inclusive) indicate that the numbers in the dataset should be interpreted 00558 as being drawn from a given distribution. Most such distributions have 00559 auxiliary parameters (e.g., NIFTI_INTENT_TTEST has 1 DOF parameter). 00560 00561 If the dataset DOES NOT have a 5th dimension, then the auxiliary parameters 00562 are the same for each voxel, and are given in header fields intent_p1, 00563 intent_p2, and intent_p3. 00564 00565 If the dataset DOES have a 5th dimension, then the auxiliary parameters 00566 are different for each voxel. For example, the header values 00567 - dim[0] = 5 00568 - dim[1] = 128 00569 - dim[2] = 128 00570 - dim[3] = 1 (indicates a single slice) 00571 - dim[4] = 1 (indicates no time axis) 00572 - dim[5] = 2 00573 - datatype = DT_FLOAT 00574 - intent_code = NIFTI_INTENT_TTEST 00575 mean that this is a 2D dataset (128x128) of t-statistics, with the 00576 t-statistic being in the first "plane" of data and the degrees-of-freedom 00577 parameter being in the second "plane" of data. 00578 00579 If the dataset 5th dimension is used to store the voxel-wise statistical 00580 parameters, then dim[5] must be 1 plus the number of parameters required 00581 by that distribution (e.g., intent_code=NIFTI_INTENT_TTEST implies dim[5] 00582 must be 2, as in the example just above). 00583 00584 Note: intent_code values 2..10 are compatible with AFNI 1.5x (which is 00585 why there is no code with value=1, which is obsolescent in AFNI). 00586 00587 OTHER INTENTIONS: 00588 ---------------- 00589 The purpose of the intent_* fields is to help interpret the values 00590 stored in the dataset. Some non-statistical values for intent_code 00591 and conventions are provided for storing other complex data types. 00592 00593 The intent_name field provides space for a 15 character (plus 0 byte) 00594 'name' string for the type of data stored. Examples: 00595 - intent_code = NIFTI_INTENT_ESTIMATE; intent_name = "T1"; 00596 could be used to signify that the voxel values are estimates of the 00597 NMR parameter T1. 00598 - intent_code = NIFTI_INTENT_TTEST; intent_name = "House"; 00599 could be used to signify that the voxel values are t-statistics 00600 for the significance of 'activation' response to a House stimulus. 00601 - intent_code = NIFTI_INTENT_DISPVECT; intent_name = "ToMNI152"; 00602 could be used to signify that the voxel values are a displacement 00603 vector that transforms each voxel (x,y,z) location to the 00604 corresponding location in the MNI152 standard brain. 00605 - intent_code = NIFTI_INTENT_SYMMATRIX; intent_name = "DTI"; 00606 could be used to signify that the voxel values comprise a diffusion 00607 tensor image. 00608 00609 If no data name is implied or needed, intent_name[0] should be set to 0. 00610 -----------------------------------------------------------------------------*/ 00611 00612 /*! default: no intention is indicated in the header. */ 00613 00614 #define NIFTI_INTENT_NONE 0 00615 00616 /*-------- These codes are for probability distributions ---------------*/ 00617 /* Most distributions have a number of parameters, 00618 below denoted by p1, p2, and p3, and stored in 00619 - intent_p1, intent_p2, intent_p3 if dataset doesn't have 5th dimension 00620 - image data array if dataset does have 5th dimension 00621 00622 Functions to compute with many of the distributions below can be found 00623 in the CDF library from U Texas. 00624 00625 Formulas for and discussions of these distributions can be found in the 00626 following books: 00627 00628 [U] Univariate Discrete Distributions, 00629 NL Johnson, S Kotz, AW Kemp. 00630 00631 [C1] Continuous Univariate Distributions, vol. 1, 00632 NL Johnson, S Kotz, N Balakrishnan. 00633 00634 [C2] Continuous Univariate Distributions, vol. 2, 00635 NL Johnson, S Kotz, N Balakrishnan. */ 00636 /*----------------------------------------------------------------------*/ 00637 00638 /*! [C2, chap 32] Correlation coefficient R (1 param): 00639 p1 = degrees of freedom 00640 R/sqrt(1-R*R) is t-distributed with p1 DOF. */ 00641 00642 #define NIFTI_INTENT_CORREL 2 00643 00644 /*! [C2, chap 28] Student t statistic (1 param): p1 = DOF. */ 00645 00646 #define NIFTI_INTENT_TTEST 3 00647 00648 /*! [C2, chap 27] Fisher F statistic (2 params): 00649 p1 = numerator DOF, p2 = denominator DOF. */ 00650 00651 #define NIFTI_INTENT_FTEST 4 00652 00653 /*! [C1, chap 13] Standard normal (0 params): Density = N(0,1). */ 00654 00655 #define NIFTI_INTENT_ZSCORE 5 00656 00657 /*! [C1, chap 18] Chi-squared (1 param): p1 = DOF. 00658 Density(x) proportional to exp(-x/2) * x^(p1/2-1). */ 00659 00660 #define NIFTI_INTENT_CHISQ 6 00661 00662 /*! [C2, chap 25] Beta distribution (2 params): p1=a, p2=b. 00663 Density(x) proportional to x^(a-1) * (1-x)^(b-1). */ 00664 00665 #define NIFTI_INTENT_BETA 7 00666 00667 /*! [U, chap 3] Binomial distribution (2 params): 00668 p1 = number of trials, p2 = probability per trial. 00669 Prob(x) = (p1 choose x) * p2^x * (1-p2)^(p1-x), for x=0,1,...,p1. */ 00670 00671 #define NIFTI_INTENT_BINOM 8 00672 00673 /*! [C1, chap 17] Gamma distribution (2 params): 00674 p1 = shape, p2 = scale. 00675 Density(x) proportional to x^(p1-1) * exp(-p2*x). */ 00676 00677 #define NIFTI_INTENT_GAMMA 9 00678 00679 /*! [U, chap 4] Poisson distribution (1 param): p1 = mean. 00680 Prob(x) = exp(-p1) * p1^x / x! , for x=0,1,2,.... */ 00681 00682 #define NIFTI_INTENT_POISSON 10 00683 00684 /*! [C1, chap 13] Normal distribution (2 params): 00685 p1 = mean, p2 = standard deviation. */ 00686 00687 #define NIFTI_INTENT_NORMAL 11 00688 00689 /*! [C2, chap 30] Noncentral F statistic (3 params): 00690 p1 = numerator DOF, p2 = denominator DOF, 00691 p3 = numerator noncentrality parameter. */ 00692 00693 #define NIFTI_INTENT_FTEST_NONC 12 00694 00695 /*! [C2, chap 29] Noncentral chi-squared statistic (2 params): 00696 p1 = DOF, p2 = noncentrality parameter. */ 00697 00698 #define NIFTI_INTENT_CHISQ_NONC 13 00699 00700 /*! [C2, chap 23] Logistic distribution (2 params): 00701 p1 = location, p2 = scale. 00702 Density(x) proportional to sech^2((x-p1)/(2*p2)). */ 00703 00704 #define NIFTI_INTENT_LOGISTIC 14 00705 00706 /*! [C2, chap 24] Laplace distribution (2 params): 00707 p1 = location, p2 = scale. 00708 Density(x) proportional to exp(-abs(x-p1)/p2). */ 00709 00710 #define NIFTI_INTENT_LAPLACE 15 00711 00712 /*! [C2, chap 26] Uniform distribution: p1 = lower end, p2 = upper end. */ 00713 00714 #define NIFTI_INTENT_UNIFORM 16 00715 00716 /*! [C2, chap 31] Noncentral t statistic (2 params): 00717 p1 = DOF, p2 = noncentrality parameter. */ 00718 00719 #define NIFTI_INTENT_TTEST_NONC 17 00720 00721 /*! [C1, chap 21] Weibull distribution (3 params): 00722 p1 = location, p2 = scale, p3 = power. 00723 Density(x) proportional to 00724 ((x-p1)/p2)^(p3-1) * exp(-((x-p1)/p2)^p3) for x > p1. */ 00725 00726 #define NIFTI_INTENT_WEIBULL 18 00727 00728 /*! [C1, chap 18] Chi distribution (1 param): p1 = DOF. 00729 Density(x) proportional to x^(p1-1) * exp(-x^2/2) for x > 0. 00730 p1 = 1 = 'half normal' distribution 00731 p1 = 2 = Rayleigh distribution 00732 p1 = 3 = Maxwell-Boltzmann distribution. */ 00733 00734 #define NIFTI_INTENT_CHI 19 00735 00736 /*! [C1, chap 15] Inverse Gaussian (2 params): 00737 p1 = mu, p2 = lambda 00738 Density(x) proportional to 00739 exp(-p2*(x-p1)^2/(2*p1^2*x)) / x^3 for x > 0. */ 00740 00741 #define NIFTI_INTENT_INVGAUSS 20 00742 00743 /*! [C2, chap 22] Extreme value type I (2 params): 00744 p1 = location, p2 = scale 00745 cdf(x) = exp(-exp(-(x-p1)/p2)). */ 00746 00747 #define NIFTI_INTENT_EXTVAL 21 00748 00749 /*! Data is a 'p-value' (no params). */ 00750 00751 #define NIFTI_INTENT_PVAL 22 00752 00753 /*! Data is ln(p-value) (no params). */ 00754 00755 #define NIFTI_INTENT_LOGPVAL 23 00756 00757 /*! Data is log10(p-value) (no params). */ 00758 00759 #define NIFTI_INTENT_LOG10PVAL 24 00760 00761 /*! Smallest intent_code that indicates a statistic. */ 00762 00763 #define NIFTI_FIRST_STATCODE 2 00764 00765 /*! Largest intent_code that indicates a statistic. */ 00766 00767 #define NIFTI_LAST_STATCODE 24 00768 00769 /*---------- these values for intent_code aren't for statistics ----------*/ 00770 00771 /*! To signify that the value at each voxel is an estimate 00772 of some parameter, set intent_code = NIFTI_INTENT_ESTIMATE. 00773 The name of the parameter may be stored in intent_name. */ 00774 00775 #define NIFTI_INTENT_ESTIMATE 1001 00776 00777 /*! To signify that the value at each voxel is an index into 00778 some set of labels, set intent_code = NIFTI_INTENT_LABEL. 00779 The filename with the labels may stored in aux_file. */ 00780 00781 #define NIFTI_INTENT_LABEL 1002 00782 00783 /*! To signify that the value at each voxel is an index into the 00784 NeuroNames labels set, set intent_code = NIFTI_INTENT_NEURONAME. */ 00785 00786 #define NIFTI_INTENT_NEURONAME 1003 00787 00788 /*! To store an M x N matrix at each voxel: 00789 - dataset must have a 5th dimension (dim[0]=5 and dim[5]>1) 00790 - intent_code must be NIFTI_INTENT_GENMATRIX 00791 - dim[5] must be M*N 00792 - intent_p1 must be M (in float format) 00793 - intent_p2 must be N (ditto) 00794 - the matrix values A[i][[j] are stored in row-order: 00795 - A[0][0] A[0][1] ... A[0][N-1] 00796 - A[1][0] A[1][1] ... A[1][N-1] 00797 - etc., until 00798 - A[M-1][0] A[M-1][1] ... A[M-1][N-1] */ 00799 00800 #define NIFTI_INTENT_GENMATRIX 1004 00801 00802 /*! To store an NxN symmetric matrix at each voxel: 00803 - dataset must have a 5th dimension 00804 - intent_code must be NIFTI_INTENT_SYMMATRIX 00805 - dim[5] must be N*(N+1)/2 00806 - intent_p1 must be N (in float format) 00807 - the matrix values A[i][[j] are stored in row-order: 00808 - A[0][0] 00809 - A[1][0] A[1][1] 00810 - A[2][0] A[2][1] A[2][2] 00811 - etc.: row-by-row */ 00812 00813 #define NIFTI_INTENT_SYMMATRIX 1005 00814 00815 /*! To signify that the vector value at each voxel is to be taken 00816 as a displacement field or vector: 00817 - dataset must have a 5th dimension 00818 - intent_code must be NIFTI_INTENT_DISPVECT 00819 - dim[5] must be the dimensionality of the displacment 00820 vector (e.g., 3 for spatial displacement, 2 for in-plane) */ 00821 00822 #define NIFTI_INTENT_DISPVECT 1006 /* specifically for displacements */ 00823 #define NIFTI_INTENT_VECTOR 1007 /* for any other type of vector */ 00824 00825 /*! To signify that the vector value at each voxel is really a 00826 spatial coordinate (e.g., the vertices or nodes of a surface mesh): 00827 - dataset must have a 5th dimension 00828 - intent_code must be NIFTI_INTENT_POINTSET 00829 - dim[0] = 5 00830 - dim[1] = number of points 00831 - dim[2] = dim[3] = dim[4] = 1 00832 - dim[5] must be the dimensionality of space (e.g., 3 => 3D space). 00833 - intent_name may describe the object these points come from 00834 (e.g., "pial", "gray/white" , "EEG", "MEG"). */ 00835 00836 #define NIFTI_INTENT_POINTSET 1008 00837 00838 /*! To signify that the vector value at each voxel is really a triple 00839 of indexes (e.g., forming a triangle) from a pointset dataset: 00840 - dataset must have a 5th dimension 00841 - intent_code must be NIFTI_INTENT_TRIANGLE 00842 - dim[0] = 5 00843 - dim[1] = number of triangles 00844 - dim[2] = dim[3] = dim[4] = 1 00845 - dim[5] = 3 00846 - datatype should be an integer type (preferably DT_INT32) 00847 - the data values are indexes (0,1,...) into a pointset dataset. */ 00848 00849 #define NIFTI_INTENT_TRIANGLE 1009 00850 00851 /*! To signify that the vector value at each voxel is a quaternion: 00852 - dataset must have a 5th dimension 00853 - intent_code must be NIFTI_INTENT_QUATERNION 00854 - dim[0] = 5 00855 - dim[5] = 4 00856 - datatype should be a floating point type */ 00857 00858 #define NIFTI_INTENT_QUATERNION 1010 00859 00860 /*! Dimensionless value - no params - although, as in _ESTIMATE 00861 the name of the parameter may be stored in intent_name. */ 00862 00863 #define NIFTI_INTENT_DIMLESS 1011 00864 00865 /*---------------------------------------------------------------------------*/ 00866 /* 3D IMAGE (VOLUME) ORIENTATION AND LOCATION IN SPACE: 00867 --------------------------------------------------- 00868 There are 3 different methods by which continuous coordinates can 00869 attached to voxels. The discussion below emphasizes 3D volumes, and 00870 the continuous coordinates are referred to as (x,y,z). The voxel 00871 index coordinates (i.e., the array indexes) are referred to as (i,j,k), 00872 with valid ranges: 00873 i = 0 .. dim[1]-1 00874 j = 0 .. dim[2]-1 (if dim[0] >= 2) 00875 k = 0 .. dim[3]-1 (if dim[0] >= 3) 00876 The (x,y,z) coordinates refer to the CENTER of a voxel. In methods 00877 2 and 3, the (x,y,z) axes refer to a subject-based coordinate system, 00878 with 00879 +x = Right +y = Anterior +z = Superior. 00880 This is a right-handed coordinate system. However, the exact direction 00881 these axes point with respect to the subject depends on qform_code 00882 (Method 2) and sform_code (Method 3). 00883 00884 N.B.: The i index varies most rapidly, j index next, k index slowest. 00885 Thus, voxel (i,j,k) is stored starting at location 00886 (i + j*dim[1] + k*dim[1]*dim[2]) * (bitpix/8) 00887 into the dataset array. 00888 00889 N.B.: The ANALYZE 7.5 coordinate system is 00890 +x = Left +y = Anterior +z = Superior 00891 which is a left-handed coordinate system. This backwardness is 00892 too difficult to tolerate, so this NIFTI-1 standard specifies the 00893 coordinate order which is most common in functional neuroimaging. 00894 00895 N.B.: The 3 methods below all give the locations of the voxel centers 00896 in the (x,y,z) coordinate system. In many cases, programs will wish 00897 to display image data on some other grid. In such a case, the program 00898 will need to convert its desired (x,y,z) values into (i,j,k) values 00899 in order to extract (or interpolate) the image data. This operation 00900 would be done with the inverse transformation to those described below. 00901 00902 N.B.: Method 2 uses a factor 'qfac' which is either -1 or 1; qfac is 00903 stored in the otherwise unused pixdim[0]. If pixdim[0]=0.0 (which 00904 should not occur), we take qfac=1. Of course, pixdim[0] is only used 00905 when reading a NIFTI-1 header, not when reading an ANALYZE 7.5 header. 00906 00907 N.B.: The units of (x,y,z) can be specified using the xyzt_units field. 00908 00909 METHOD 1 (the "old" way, used only when qform_code = 0): 00910 ------------------------------------------------------- 00911 The coordinate mapping from (i,j,k) to (x,y,z) is the ANALYZE 00912 7.5 way. This is a simple scaling relationship: 00913 00914 x = pixdim[1] * i 00915 y = pixdim[2] * j 00916 z = pixdim[3] * k 00917 00918 No particular spatial orientation is attached to these (x,y,z) 00919 coordinates. (NIFTI-1 does not have the ANALYZE 7.5 orient field, 00920 which is not general and is often not set properly.) This method 00921 is not recommended, and is present mainly for compatibility with 00922 ANALYZE 7.5 files. 00923 00924 METHOD 2 (used when qform_code > 0, which should be the "normal" case): 00925 --------------------------------------------------------------------- 00926 The (x,y,z) coordinates are given by the pixdim[] scales, a rotation 00927 matrix, and a shift. This method is intended to represent 00928 "scanner-anatomical" coordinates, which are often embedded in the 00929 image header (e.g., DICOM fields (0020,0032), (0020,0037), (0028,0030), 00930 and (0018,0050)), and represent the nominal orientation and location of 00931 the data. This method can also be used to represent "aligned" 00932 coordinates, which would typically result from some post-acquisition 00933 alignment of the volume to a standard orientation (e.g., the same 00934 subject on another day, or a rigid rotation to true anatomical 00935 orientation from the tilted position of the subject in the scanner). 00936 The formula for (x,y,z) in terms of header parameters and (i,j,k) is: 00937 00938 [ x ] [ R11 R12 R13 ] [ pixdim[1] * i ] [ qoffset_x ] 00939 [ y ] = [ R21 R22 R23 ] [ pixdim[2] * j ] + [ qoffset_y ] 00940 [ z ] [ R31 R32 R33 ] [ qfac * pixdim[3] * k ] [ qoffset_z ] 00941 00942 The qoffset_* shifts are in the NIFTI-1 header. Note that the center 00943 of the (i,j,k)=(0,0,0) voxel (first value in the dataset array) is 00944 just (x,y,z)=(qoffset_x,qoffset_y,qoffset_z). 00945 00946 The rotation matrix R is calculated from the quatern_* parameters. 00947 This calculation is described below. 00948 00949 The scaling factor qfac is either 1 or -1. The rotation matrix R 00950 defined by the quaternion parameters is "proper" (has determinant 1). 00951 This may not fit the needs of the data; for example, if the image 00952 grid is 00953 i increases from Left-to-Right 00954 j increases from Anterior-to-Posterior 00955 k increases from Inferior-to-Superior 00956 Then (i,j,k) is a left-handed triple. In this example, if qfac=1, 00957 the R matrix would have to be 00958 00959 [ 1 0 0 ] 00960 [ 0 -1 0 ] which is "improper" (determinant = -1). 00961 [ 0 0 1 ] 00962 00963 If we set qfac=-1, then the R matrix would be 00964 00965 [ 1 0 0 ] 00966 [ 0 -1 0 ] which is proper. 00967 [ 0 0 -1 ] 00968 00969 This R matrix is represented by quaternion [a,b,c,d] = [0,1,0,0] 00970 (which encodes a 180 degree rotation about the x-axis). 00971 00972 METHOD 3 (used when sform_code > 0): 00973 ----------------------------------- 00974 The (x,y,z) coordinates are given by a general affine transformation 00975 of the (i,j,k) indexes: 00976 00977 x = srow_x[0] * i + srow_x[1] * j + srow_x[2] * k + srow_x[3] 00978 y = srow_y[0] * i + srow_y[1] * j + srow_y[2] * k + srow_y[3] 00979 z = srow_z[0] * i + srow_z[1] * j + srow_z[2] * k + srow_z[3] 00980 00981 The srow_* vectors are in the NIFTI_1 header. Note that no use is 00982 made of pixdim[] in this method. 00983 00984 WHY 3 METHODS? 00985 -------------- 00986 Method 1 is provided only for backwards compatibility. The intention 00987 is that Method 2 (qform_code > 0) represents the nominal voxel locations 00988 as reported by the scanner, or as rotated to some fiducial orientation and 00989 location. Method 3, if present (sform_code > 0), is to be used to give 00990 the location of the voxels in some standard space. The sform_code 00991 indicates which standard space is present. Both methods 2 and 3 can be 00992 present, and be useful in different contexts (method 2 for displaying the 00993 data on its original grid; method 3 for displaying it on a standard grid). 00994 00995 In this scheme, a dataset would originally be set up so that the 00996 Method 2 coordinates represent what the scanner reported. Later, 00997 a registration to some standard space can be computed and inserted 00998 in the header. Image display software can use either transform, 00999 depending on its purposes and needs. 01000 01001 In Method 2, the origin of coordinates would generally be whatever 01002 the scanner origin is; for example, in MRI, (0,0,0) is the center 01003 of the gradient coil. 01004 01005 In Method 3, the origin of coordinates would depend on the value 01006 of sform_code; for example, for the Talairach coordinate system, 01007 (0,0,0) corresponds to the Anterior Commissure. 01008 01009 QUATERNION REPRESENTATION OF ROTATION MATRIX (METHOD 2) 01010 ------------------------------------------------------- 01011 The orientation of the (x,y,z) axes relative to the (i,j,k) axes 01012 in 3D space is specified using a unit quaternion [a,b,c,d], where 01013 a*a+b*b+c*c+d*d=1. The (b,c,d) values are all that is needed, since 01014 we require that a = sqrt(1.0-b*b-c*c-d*d) be nonnegative. The (b,c,d) 01015 values are stored in the (quatern_b,quatern_c,quatern_d) fields. 01016 01017 The quaternion representation is chosen for its compactness in 01018 representing rotations. The (proper) 3x3 rotation matrix that 01019 corresponds to [a,b,c,d] is 01020 01021 [ a*a+b*b-c*c-d*d 2*b*c-2*a*d 2*b*d+2*a*c ] 01022 R = [ 2*b*c+2*a*d a*a+c*c-b*b-d*d 2*c*d-2*a*b ] 01023 [ 2*b*d-2*a*c 2*c*d+2*a*b a*a+d*d-c*c-b*b ] 01024 01025 [ R11 R12 R13 ] 01026 = [ R21 R22 R23 ] 01027 [ R31 R32 R33 ] 01028 01029 If (p,q,r) is a unit 3-vector, then rotation of angle h about that 01030 direction is represented by the quaternion 01031 01032 [a,b,c,d] = [cos(h/2), p*sin(h/2), q*sin(h/2), r*sin(h/2)]. 01033 01034 Requiring a >= 0 is equivalent to requiring -Pi <= h <= Pi. (Note that 01035 [-a,-b,-c,-d] represents the same rotation as [a,b,c,d]; there are 2 01036 quaternions that can be used to represent a given rotation matrix R.) 01037 To rotate a 3-vector (x,y,z) using quaternions, we compute the 01038 quaternion product 01039 01040 [0,x',y',z'] = [a,b,c,d] * [0,x,y,z] * [a,-b,-c,-d] 01041 01042 which is equivalent to the matrix-vector multiply 01043 01044 [ x' ] [ x ] 01045 [ y' ] = R [ y ] (equivalence depends on a*a+b*b+c*c+d*d=1) 01046 [ z' ] [ z ] 01047 01048 Multiplication of 2 quaternions is defined by the following: 01049 01050 [a,b,c,d] = a*1 + b*I + c*J + d*K 01051 where 01052 I*I = J*J = K*K = -1 (I,J,K are square roots of -1) 01053 I*J = K J*K = I K*I = J 01054 J*I = -K K*J = -I I*K = -J (not commutative!) 01055 For example 01056 [a,b,0,0] * [0,0,0,1] = [0,0,-b,a] 01057 since this expands to 01058 (a+b*I)*(K) = (a*K+b*I*K) = (a*K-b*J). 01059 01060 The above formula shows how to go from quaternion (b,c,d) to 01061 rotation matrix and direction cosines. Conversely, given R, 01062 we can compute the fields for the NIFTI-1 header by 01063 01064 a = 0.5 * sqrt(1+R11+R22+R33) (not stored) 01065 b = 0.25 * (R32-R23) / a => quatern_b 01066 c = 0.25 * (R13-R31) / a => quatern_c 01067 d = 0.25 * (R21-R12) / a => quatern_d 01068 01069 If a=0 (a 180 degree rotation), alternative formulas are needed. 01070 See the nifti1_io.c function mat44_to_quatern() for an implementation 01071 of the various cases in converting R to [a,b,c,d]. 01072 01073 Note that R-transpose (= R-inverse) would lead to the quaternion 01074 [a,-b,-c,-d]. 01075 01076 The choice to specify the qoffset_x (etc.) values in the final 01077 coordinate system is partly to make it easy to convert DICOM images to 01078 this format. The DICOM attribute "Image Position (Patient)" (0020,0032) 01079 stores the (Xd,Yd,Zd) coordinates of the center of the first voxel. 01080 Here, (Xd,Yd,Zd) refer to DICOM coordinates, and Xd=-x, Yd=-y, Zd=z, 01081 where (x,y,z) refers to the NIFTI coordinate system discussed above. 01082 (i.e., DICOM +Xd is Left, +Yd is Posterior, +Zd is Superior, 01083 whereas +x is Right, +y is Anterior , +z is Superior. ) 01084 Thus, if the (0020,0032) DICOM attribute is extracted into (px,py,pz), then 01085 qoffset_x = -px qoffset_y = -py qoffset_z = pz 01086 is a reasonable setting when qform_code=NIFTI_XFORM_SCANNER_ANAT. 01087 01088 That is, DICOM's coordinate system is 180 degrees rotated about the z-axis 01089 from the neuroscience/NIFTI coordinate system. To transform between DICOM 01090 and NIFTI, you just have to negate the x- and y-coordinates. 01091 01092 The DICOM attribute (0020,0037) "Image Orientation (Patient)" gives the 01093 orientation of the x- and y-axes of the image data in terms of 2 3-vectors. 01094 The first vector is a unit vector along the x-axis, and the second is 01095 along the y-axis. If the (0020,0037) attribute is extracted into the 01096 value (xa,xb,xc,ya,yb,yc), then the first two columns of the R matrix 01097 would be 01098 [ -xa -ya ] 01099 [ -xb -yb ] 01100 [ xc yc ] 01101 The negations are because DICOM's x- and y-axes are reversed relative 01102 to NIFTI's. The third column of the R matrix gives the direction of 01103 displacement (relative to the subject) along the slice-wise direction. 01104 This orientation is not encoded in the DICOM standard in a simple way; 01105 DICOM is mostly concerned with 2D images. The third column of R will be 01106 either the cross-product of the first 2 columns or its negative. It is 01107 possible to infer the sign of the 3rd column by examining the coordinates 01108 in DICOM attribute (0020,0032) "Image Position (Patient)" for successive 01109 slices. However, this method occasionally fails for reasons that I 01110 (RW Cox) do not understand. 01111 -----------------------------------------------------------------------------*/ 01112 01113 /* [qs]form_code value: */ /* x,y,z coordinate system refers to: */ 01114 /*-----------------------*/ /*---------------------------------------*/ 01115 01116 /*! Arbitrary coordinates (Method 1). */ 01117 01118 #define NIFTI_XFORM_UNKNOWN 0 01119 01120 /*! Scanner-based anatomical coordinates */ 01121 01122 #define NIFTI_XFORM_SCANNER_ANAT 1 01123 01124 /*! Coordinates aligned to another file's, 01125 or to anatomical "truth". */ 01126 01127 #define NIFTI_XFORM_ALIGNED_ANAT 2 01128 01129 /*! Coordinates aligned to Talairach- 01130 Tournoux Atlas; (0,0,0)=AC, etc. */ 01131 01132 #define NIFTI_XFORM_TALAIRACH 3 01133 01134 /*! MNI 152 normalized coordinates. */ 01135 01136 #define NIFTI_XFORM_MNI_152 4 01137 01138 /*---------------------------------------------------------------------------*/ 01139 /* UNITS OF SPATIAL AND TEMPORAL DIMENSIONS: 01140 ---------------------------------------- 01141 The codes below can be used in xyzt_units to indicate the units of pixdim. 01142 As noted earlier, dimensions 1,2,3 are for x,y,z; dimension 4 is for 01143 time (t). 01144 - If dim[4]=1 or dim[0] < 4, there is no time axis. 01145 - A single time series (no space) would be specified with 01146 - dim[0] = 4 (for scalar data) or dim[0] = 5 (for vector data) 01147 - dim[1] = dim[2] = dim[3] = 1 01148 - dim[4] = number of time points 01149 - pixdim[4] = time step 01150 - xyzt_units indicates units of pixdim[4] 01151 - dim[5] = number of values stored at each time point 01152 01153 Bits 0..2 of xyzt_units specify the units of pixdim[1..3] 01154 (e.g., spatial units are values 1..7). 01155 Bits 3..5 of xyzt_units specify the units of pixdim[4] 01156 (e.g., temporal units are multiples of 8). 01157 01158 This compression of 2 distinct concepts into 1 byte is due to the 01159 limited space available in the 348 byte ANALYZE 7.5 header. The 01160 macros XYZT_TO_SPACE and XYZT_TO_TIME can be used to mask off the 01161 undesired bits from the xyzt_units fields, leaving "pure" space 01162 and time codes. Inversely, the macro SPACE_TIME_TO_XYZT can be 01163 used to assemble a space code (0,1,2,...,7) with a time code 01164 (0,8,16,32,...,56) into the combined value for xyzt_units. 01165 01166 Note that codes are provided to indicate the "time" axis units are 01167 actually frequency in Hertz (_HZ) or in part-per-million (_PPM). 01168 01169 The toffset field can be used to indicate a nonzero start point for 01170 the time axis. That is, time point #m is at t=toffset+m*pixdim[4] 01171 for m=0..dim[4]-1. 01172 -----------------------------------------------------------------------------*/ 01173 01174 /*! NIFTI code for unspecified units. */ 01175 #define NIFTI_UNITS_UNKNOWN 0 01176 01177 /** Space codes are multiples of 1. **/ 01178 /*! NIFTI code for meters. */ 01179 #define NIFTI_UNITS_METER 1 01180 /*! NIFTI code for millimeters. */ 01181 #define NIFTI_UNITS_MM 2 01182 /*! NIFTI code for micrometers. */ 01183 #define NIFTI_UNITS_MICRON 3 01184 01185 /** Time codes are multiples of 8. **/ 01186 /*! NIFTI code for seconds. */ 01187 #define NIFTI_UNITS_SEC 8 01188 /*! NIFTI code for milliseconds. */ 01189 #define NIFTI_UNITS_MSEC 16 01190 /*! NIFTI code for microseconds. */ 01191 #define NIFTI_UNITS_USEC 24 01192 01193 /*** These units are for spectral data: ***/ 01194 /*! NIFTI code for Hertz. */ 01195 #define NIFTI_UNITS_HZ 32 01196 /*! NIFTI code for ppm. */ 01197 #define NIFTI_UNITS_PPM 40 01198 /*! NIFTI code for radians. */ 01199 #define NIFTI_UNITS_RADS 48 01200 01201 #undef XYZT_TO_SPACE 01202 #undef XYZT_TO_TIME 01203 #define XYZT_TO_SPACE(xyzt) ( (xyzt) & 0x07 ) 01204 #define XYZT_TO_TIME(xyzt) ( (xyzt) & 0x38 ) 01205 01206 #undef SPACE_TIME_TO_XYZT 01207 #define SPACE_TIME_TO_XYZT(ss,tt) ( (((char)(ss)) & 0x07) \ 01208 | (((char)(tt)) & 0x38) ) 01209 01210 /*---------------------------------------------------------------------------*/ 01211 /* MRI-SPECIFIC SPATIAL AND TEMPORAL INFORMATION: 01212 --------------------------------------------- 01213 A few fields are provided to store some extra information 01214 that is sometimes important when storing the image data 01215 from an FMRI time series experiment. (After processing such 01216 data into statistical images, these fields are not likely 01217 to be useful.) 01218 01219 { freq_dim } = These fields encode which spatial dimension (1,2, or 3) 01220 { phase_dim } = corresponds to which acquisition dimension for MRI data. 01221 { slice_dim } = 01222 Examples: 01223 Rectangular scan multi-slice EPI: 01224 freq_dim = 1 phase_dim = 2 slice_dim = 3 (or some permutation) 01225 Spiral scan multi-slice EPI: 01226 freq_dim = phase_dim = 0 slice_dim = 3 01227 since the concepts of frequency- and phase-encoding directions 01228 don't apply to spiral scan 01229 01230 slice_duration = If this is positive, AND if slice_dim is nonzero, 01231 indicates the amount of time used to acquire 1 slice. 01232 slice_duration*dim[slice_dim] can be less than pixdim[4] 01233 with a clustered acquisition method, for example. 01234 01235 slice_code = If this is nonzero, AND if slice_dim is nonzero, AND 01236 if slice_duration is positive, indicates the timing 01237 pattern of the slice acquisition. The following codes 01238 are defined: 01239 NIFTI_SLICE_SEQ_INC 01240 NIFTI_SLICE_SEQ_DEC 01241 NIFTI_SLICE_ALT_INC 01242 NIFTI_SLICE_ALT_DEC 01243 { slice_start } = Indicates the start and end of the slice acquisition 01244 { slice_end } = pattern, when slice_code is nonzero. These values 01245 are present to allow for the possible addition of 01246 "padded" slices at either end of the volume, which 01247 don't fit into the slice timing pattern. If there 01248 are no padding slices, then slice_start=0 and 01249 slice_end=dim[slice_dim]-1 are the correct values. 01250 For these values to be meaningful, slice_start must 01251 be non-negative and slice_end must be greater than 01252 slice_start. 01253 01254 The following table indicates the slice timing pattern, relative to 01255 time=0 for the first slice acquired, for some sample cases. Here, 01256 dim[slice_dim]=7 (there are 7 slices, labeled 0..6), slice_duration=0.1, 01257 and slice_start=1, slice_end=5 (1 padded slice on each end). 01258 01259 slice 01260 index SEQ_INC SEQ_DEC ALT_INC ALT_DEC 01261 6 -- n/a n/a n/a n/a n/a = not applicable 01262 5 -- 0.4 0.0 0.2 0.0 (slice time offset 01263 4 -- 0.3 0.1 0.4 0.3 doesn't apply to 01264 3 -- 0.2 0.2 0.1 0.1 slices outside range 01265 2 -- 0.1 0.3 0.3 0.4 slice_start..slice_end) 01266 1 -- 0.0 0.4 0.0 0.2 01267 0 -- n/a n/a n/a n/a 01268 01269 The fields freq_dim, phase_dim, slice_dim are all squished into the single 01270 byte field dim_info (2 bits each, since the values for each field are 01271 limited to the range 0..3). This unpleasantness is due to lack of space 01272 in the 348 byte allowance. 01273 01274 The macros DIM_INFO_TO_FREQ_DIM, DIM_INFO_TO_PHASE_DIM, and 01275 DIM_INFO_TO_SLICE_DIM can be used to extract these values from the 01276 dim_info byte. 01277 01278 The macro FPS_INTO_DIM_INFO can be used to put these 3 values 01279 into the dim_info byte. 01280 -----------------------------------------------------------------------------*/ 01281 01282 #undef DIM_INFO_TO_FREQ_DIM 01283 #undef DIM_INFO_TO_PHASE_DIM 01284 #undef DIM_INFO_TO_SLICE_DIM 01285 01286 #define DIM_INFO_TO_FREQ_DIM(di) ( ((di) ) & 0x03 ) 01287 #define DIM_INFO_TO_PHASE_DIM(di) ( ((di) >> 2) & 0x03 ) 01288 #define DIM_INFO_TO_SLICE_DIM(di) ( ((di) >> 4) & 0x03 ) 01289 01290 #undef FPS_INTO_DIM_INFO 01291 #define FPS_INTO_DIM_INFO(fd,pd,sd) ( ( ( ((char)(fd)) & 0x03) ) | \ 01292 ( ( ((char)(pd)) & 0x03) << 2 ) | \ 01293 ( ( ((char)(sd)) & 0x03) << 4 ) ) 01294 01295 #define NIFTI_SLICE_UNKNOWN 0 01296 #define NIFTI_SLICE_SEQ_INC 1 01297 #define NIFTI_SLICE_SEQ_DEC 2 01298 #define NIFTI_SLICE_ALT_INC 3 01299 #define NIFTI_SLICE_ALT_DEC 4 01300 01301 /*---------------------------------------------------------------------------*/ 01302 /* UNUSED FIELDS: 01303 ------------- 01304 Some of the ANALYZE 7.5 fields marked as ++UNUSED++ may need to be set 01305 to particular values for compatibility with other programs. The issue 01306 of interoperability of ANALYZE 7.5 files is a murky one -- not all 01307 programs require exactly the same set of fields. (Unobscuring this 01308 murkiness is a principal motivation behind NIFTI-1.) 01309 01310 Some of the fields that may need to be set for other (non-NIFTI aware) 01311 software to be happy are: 01312 01313 extents dbh.h says this should be 16384 01314 regular dbh.h says this should be the character 'r' 01315 glmin, } dbh.h says these values should be the min and max voxel 01316 glmax } values for the entire dataset 01317 01318 It is best to initialize ALL fields in the NIFTI-1 header to 0 01319 (e.g., with calloc()), then fill in what is needed. 01320 -----------------------------------------------------------------------------*/ 01321 01322 /*---------------------------------------------------------------------------*/ 01323 /* MISCELLANEOUS C MACROS 01324 -----------------------------------------------------------------------------*/ 01325 01326 /*.................*/ 01327 /*! Given a nifti_1_header struct, check if it has a good magic number. 01328 Returns NIFTI version number (1..9) if magic is good, 0 if it is not. */ 01329 01330 #define NIFTI_VERSION(h) \ 01331 ( ( (h).magic[0]=='n' && (h).magic[3]=='\0' && \ 01332 ( (h).magic[1]=='i' || (h).magic[1]=='+' ) && \ 01333 ( (h).magic[2]>='1' && (h).magic[2]<='9' ) ) \ 01334 ? (h).magic[2]-'0' : 0 ) 01335 01336 /*.................*/ 01337 /*! Check if a nifti_1_header struct says if the data is stored in the 01338 same file or in a separate file. Returns 1 if the data is in the same 01339 file as the header, 0 if it is not. */ 01340 01341 #define NIFTI_ONEFILE(h) ( (h).magic[1] == '+' ) 01342 01343 /*.................*/ 01344 /*! Check if a nifti_1_header struct needs to be byte swapped. 01345 Returns 1 if it needs to be swapped, 0 if it does not. */ 01346 01347 #define NIFTI_NEEDS_SWAP(h) ( (h).dim[0] < 0 || (h).dim[0] > 7 ) 01348 01349 /*.................*/ 01350 /*! Check if a nifti_1_header struct contains a 5th (vector) dimension. 01351 Returns size of 5th dimension if > 1, returns 0 otherwise. */ 01352 01353 #define NIFTI_5TH_DIM(h) ( ((h).dim[0]>4 && (h).dim[5]>1) ? (h).dim[5] : 0 ) 01354 01355 /*****************************************************************************/ 01356 01357 /*=================*/ 01358 #ifdef __cplusplus 01359 } 01360 #endif 01361 /*=================*/ 01362 01363 #endif /* _NIFTI_HEADER_ */