AFNI Message Board

Dear AFNI users-

We are very pleased to announce that the new AFNI Message Board framework is up! Please join us at:

https://discuss.afni.nimh.nih.gov

Existing user accounts have been migrated, so returning users can login by requesting a password reset. New users can create accounts, as well, through a standard account creation process. Please note that these setup emails might initially go to spam folders (esp. for NIH users!), so please check those locations in the beginning.

The current Message Board discussion threads have been migrated to the new framework. The current Message Board will remain visible, but read-only, for a little while.

Sincerely, AFNI HQ

History of AFNI updates  

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May 20, 2013 02:14PM
Hi David,
Thanks a lot for bringing up the point about a principled approach for determining the combination of p-threshold and extent threshold for achieving a desired alpha value (familywise error rate). Multiple combinations of p-threshold and extent threshold give the same alpha value. Conjunction analyses (where you try to find overlap of activity across conditions in order to determine multimodal brain regions) can give totally different results depending on the exact combination of p-threshold and extent threshold used for controlling familywise error. But other than conjunction analyses, I have not come across any other analysis where my results are too sensitive to this combination.

I agree with Rick that there are no wrong or right combinations, there are only reasonable and unreasonable combinations, depending on what effect you are trying to tease out. For a conjunction analysis, for example, it will be unreasonable to use p=0.05 and extent=80 voxels even though this might achieve alpha=0.05 because such a combination will almost always yield overlap between conditions.

I also agree that the only real solution to the problem is transparency on part of the authors and a demand for transparency on part of the reviewers.
Best,
Gaurav
Subject Author Posted

Monte Carlo simulation ambiguity

dperlman May 19, 2013 03:35PM

Re: Monte Carlo simulation ambiguity

nick May 20, 2013 05:13AM

Re: Monte Carlo simulation ambiguity

rick reynolds May 20, 2013 10:32AM

Re: Monte Carlo simulation ambiguity

nick May 21, 2013 06:53AM

Re: Monte Carlo simulation ambiguity

dperlman May 21, 2013 11:25AM

Re: Monte Carlo simulation ambiguity

rick reynolds May 21, 2013 04:14PM

Re: Monte Carlo simulation ambiguity

dperlman May 21, 2013 07:05PM

Re: Monte Carlo simulation ambiguity

rick reynolds May 21, 2013 09:18PM

Re: Monte Carlo simulation ambiguity

gauravm May 20, 2013 02:14PM

Re: Monte Carlo simulation ambiguity

gauravm May 20, 2013 02:24PM

Re: Monte Carlo simulation ambiguity

Anonymous User July 06, 2013 11:16AM

Re: Monte Carlo simulation ambiguity

rick reynolds July 06, 2013 08:51PM

Re: Monte Carlo simulation ambiguity

Danny November 11, 2013 04:12PM

Re: Monte Carlo simulation ambiguity

rick reynolds November 12, 2013 10:06AM

Re: Monte Carlo simulation ambiguity

Danny November 13, 2013 10:05AM

Re: Monte Carlo simulation ambiguity

rick reynolds November 13, 2013 12:08PM

Re: Monte Carlo simulation ambiguity

Danny November 13, 2013 02:18PM

Re: Monte Carlo simulation ambiguity

rick reynolds November 13, 2013 03:10PM

Re: Monte Carlo simulation ambiguity

paranoidandroid January 10, 2014 07:43AM

Re: Monte Carlo simulation ambiguity

rick reynolds January 10, 2014 12:48PM

Re: Monte Carlo simulation ambiguity

paranoidandroid January 12, 2014 12:52PM