John,
You can use 3dttest++ to
1) run one-sample t-test and find the average effect of each condition within each group;
2) run paired t-test and compare any two conditions within each group;
3) run two-sample t-test and compare the two groups under each condition; or
4) un two-sample t-test and compare the two groups for any liner combination of multiple conditions (from the GLTs).
Alternatively you can use 3dANOVA3 -type 5 to get all you want in *one* analysis *if* you have equal number of subjects across groups. If you have unequal number of subjects across groups, use 3dMVM.
Gang