> I am curious if there is a way to correct for multiple comparisons using Guassian
> Random field theory methods instead.

Random field theory is currently not implemented in AFNI, so you'd have to try another package.

> Cluster-size methods are killing my results in smaller structures

First of all, random field theory is also a cluster-based approach for multiple testings correction. And I doubt it would please you better than 3dClustSim because typically people come in the opposite direction from what you're asking.

The so-called small volume correction (SVC) might help, but that's just a band-aid joke. See if there is room for improvement from modeling perspective. If not, I would simply present the results honestly as is, combined with the response magnitude (e.g., percent signal change). At the end of the day, it is the response amplitude (not statistics) that is of scientific interest that provides a solid base for reproducibility and cross examination.

Gang



Edited 2 time(s). Last edit at 10/31/2013 05:41PM by Gang.