To clarify further, consider two parallel runs of align_epi_anat with different deoblique options. The result is always plumb.
align_epi_anat -deoblique off -anat T1 -epi b0........ -> Plumb_T1_al + inv_mat_1
align_epi_anat -deoblique on -anat T1 -epi b0..........-> Plumb_T1_al + inv_mat_2
Is inv_mat_1 = inv_mat_2??
If not, when I attempt a reverse alignment using 3dallineate, while using which inv_mat (1 or 2) should I precede it with an additional obliquing/deobliquing step?
Hope this makes sense!