If you are not looking for session to session changes in cortical measures, then Freesurfer is pretty good at aligning multiple anatomical images and can use the two (or more) to do a type of anatomical motion correction. In the end you'll end up with only one SUMA directory for use in the surface-based analysis pipeline.
No need to align or skull-strip outside of Freesurfer - in fact doing so can cause you extra headache later on!
recon-all -s subject1 -i anatomical1.nii -i anatomical2.nii -all
Using SUMA's @SUMA_AlignToExperiment should be able to take it from there.
Edited 1 time(s). Last edit at 06/04/2014 04:18PM by Peter Molfese.