afni.nimh.nih.gov
| September 06, 2014 03:31AM | |
Hello Gang,
very good points you are making there, and I hadn't thought at all about the effect of the historical trend of increasing sample sizes on the employed statistical strategy: with the number of subjects in a study reaching sometimes the three digits, the problem of "too much" activation becomes more and more real, and a sort of "rich-world" curse!
Your idea of using the amplitude of the response as an additional parameter to gauge the spatial specificity of the activations seems very promising to me: I haven't seen any formal discussion in the literature about this, though, have you? Even better, are *you* thinking of cooking up something like this for AFNI?
thanks again for your thoughts!
giuseppe
very good points you are making there, and I hadn't thought at all about the effect of the historical trend of increasing sample sizes on the employed statistical strategy: with the number of subjects in a study reaching sometimes the three digits, the problem of "too much" activation becomes more and more real, and a sort of "rich-world" curse!
Your idea of using the amplitude of the response as an additional parameter to gauge the spatial specificity of the activations seems very promising to me: I haven't seen any formal discussion in the literature about this, though, have you? Even better, are *you* thinking of cooking up something like this for AFNI?
thanks again for your thoughts!
giuseppe
