Just to confirm - that does work on my Fedora linux system. I use a similar alias there using lucidatypewriter fonts.
alias bigafni
afni -XXXfontA '-b&h-lucidatypewriter-medium-r-normal-sans-26-190-100-100-m-159-iso8859-1' -XXXfontB '-b&h-lucidatypewriter-bold-r-normal-sans-24-240-75-75-m-140-iso8859-1' -XXXfontC '-b&h-lucidatypewriter-bold-r-normal-sans-24-240-75-75-m-140-iso8859-1' -XXXfontD '-b&h-lucidatypewriter-bold-r-normal-sans-24-240-75-75-m-140-iso8859-1'
Note to remove any extra spaces after the '\' at the end of line. To restore the default font settings, use
afni -XXX defaults
