Hi Gang,

We are using 3dMEMA to run a paired t-test. There is not much documentation on how to do a paired t-test in 3dMEMA, but I looked at the documentation of 3dttest++. It mentioned two ways for doing a paired t-test: I can either provide the paired subjects as separate sets, or I can provide a single set in which each input is the beta difference of the pair.

I think I have to use the second way in the 3dMEMA. I can get the beta difference within each pair by using 3dcalc (as suggested in 3dttest++ documentation). Should I do the same thing for corresponding tstats? This doesn't seem right. Or do you recommend running fixed effect analysis on each pair and use their outputs in the 3dMEMA?

Thank you,
Chirag