You can turn off skullstripping for anat and epi datasets in align_epi_anat.py. The weighting for the epi data is applied in any case, and there is no option to turn it off, but that's not what you are interested in here, I think. The mask for the anatomical dataset is usually computed with 3dSkullstrip. If you turn that off, then all voxels are used. You can turn the skullstripping off with "-dset1_strip None" or "-anat_has_skull no". If you want to compute alignment for a masked dataset and apply the transformation to another dataset, you can use the "-child_anat" or "-child_epi" options.