Hi PT,

Thank you for your response and time into this issue. In response:

1. Yes, both are time series (3D + t, or 4D). '3dinfo -nv' yields 8 and 13, respectively.

2. Yes, just motion (translation + rotation). Not aiming to consider distortions or any non-rigid transformations at the moment. (I think you consider translation or motion as both rigid, but new to registering so pardon me if my jargon is incorrect).

3. The resolution of both data sets are exactly the same, [0.1042 0.1849 0.2200], in mm.

4. To each other I suppose you would say. I'm really trying to register DATA2 to DATA1. DATA2 is acquired directly after DATA1. So I want to ultimately compare voxels between the two data sets. So my initial aim is to use the motion of the last time point in DATA1 and copy it to the first time point in DATA2. Then I will register the rest of DATA2 to its first time point in hopes that voxels are relatively aligned for all DATA1 and DATA2. I hope that helps. Excuse me if that isn't clear and I can aim to clarify further.

Thanks for the link to the bootcamp file. I will look it over.

Cheers,
Edwin