Peter-

I was able to copy AFNI executables and libraries from an Intel Mac, and in my limited testing all translated executables worked well. I did have to authorize the executables and libraries (e.g. "xattr -dr com.apple.quarantine 3d*"). The performance was really impressive. Many of the libraries required by AFNI (e.g. Motif) are not available natively, nor are native compilers that support OpenMP.

My own sense is that the performance of translated AFNI is good enough that it would allow productive work. At the moment, I would encourage developers but not scientists to evaluate this platform. Even if AFNI works fine, most scientists use R and Scipy, Numpy accelerated Python for many tasks. These tools will require a native Fortran compiler.

I have provided a short evaluation of this architecture here:
[github.com]