I've played around with the stat and olay resampling methods and can make the data look smoother that way, but one of the reasons I'm concerned about this is that there are some tiny clusters in the vicinity of each other that are too small to be significant that I think might combine into larger clusters if the data were a little smoother.

Changing to a continuous pane also helps the appearance some, but that's not going to help my cluster sizes.

Edit to add: What I'm showing you are stats for my control subjects only. There there are obviously significant clusters. I chose this to demonstrate the problem because that's where it's more obvious. The issue arises when I want to compare these controls to patients. That's when I get several small clusters in reasonable locations but that aren't significant.



Edited 1 time(s). Last edit at 02/24/2022 02:26PM by Phil Burton.