AFNI Message Board

Dear AFNI users-

We are very pleased to announce that the new AFNI Message Board framework is up! Please join us at:

https://discuss.afni.nimh.nih.gov

Existing user accounts have been migrated, so returning users can login by requesting a password reset. New users can create accounts, as well, through a standard account creation process. Please note that these setup emails might initially go to spam folders (esp. for NIH users!), so please check those locations in the beginning.

The current Message Board discussion threads have been migrated to the new framework. The current Message Board will remain visible, but read-only, for a little while.

Sincerely, AFNI HQ

History of AFNI updates  

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November 07, 2022 06:12PM
In short, the statistic is a basic t-stat. The process to produce it is quite involved - we're using a newer method called "lesion network mapping". Starting with a set of lesion masks and a functional connectome with resting state data, each of the lesion masks are entered as the ROI in each of the functional images, producing that many stat maps with correlation coefficients. These are aggregated with a t-test for each subject in the lesion dataset. Then we use a software called PALM (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/PALM) to do the rest - fitting a general linear model at each voxel with the t-stat as the independent variable used to predict the subject's score on some test, which produces a regression coefficient map. Then it performs permutation analysis to test each of those values for significance, which is what gives us the ultimate t-statistic as the final output. I should note here that it also gives us p-values, both corrected and uncorrected, as separate files.

Hope this answers your question,

--john
Subject Author Posted

P-value thresholding with atypical dataset Attachments

jpiaszynski November 07, 2022 05:24PM

Re: P-value thresholding with atypical dataset

ptaylor November 07, 2022 05:36PM

Re: P-value thresholding with atypical dataset

jpiaszynski November 07, 2022 06:12PM

Re: P-value thresholding with atypical dataset

ptaylor November 08, 2022 09:01AM

Re: P-value thresholding with atypical dataset

jpiaszynski November 08, 2022 02:45PM