I have a Mac G5 system, which has a 64 bit CPU but only a 32 bit OS. I am planning on making AFNI work with 64 bit systems. With some limitations. The principal limitation will be that the size of any one 3D volume will be limited to what can be addressed with a 32 bit int subscript. The way AFNI works internally is that a 4D (3D+time or bucket) dataset is stored as an array of 3D arrays; the time index is the index into the outer array and the 3D space index is the index into the inner array. Thus, as long as pointer types can store 64 bit pointers, AFNI should be able to deal with huge datasets -- as long as each 3D array is "small".
bob cox