I am trying to find the best way to analyze a block design with the following design:

ABCDABCDABCDABCD

A is a rest, the other are active conditions.

When I convole a canonical HRF with each condition, I note that the HRF for condition B is declining while the HRF for condition C is developing (increasing). This of course creates a non-orthogonal situation, and
would tend to confound the comparison between conditions.

Would 3dDeconvolve object to the non-orthogonality of these reference
vectors?

What is the best way to analyze such a design?

Would a different design be preferable? For example,
ABACADABACAD would allow the HRF to completely resolve during rest
before the active condition.

Thank you,

Lee Friedman

.... but some here don't think this would be an improvement. In this case, the A's would
probably need to be shorter than the other conditions.

I have seen your paper on task block arrangement so I know you have done substantial thinking in this area.

Your thoughts?

Lee