Hi Carl,
> Should a TR be matched to the event of interest in a block
> design (say a three second presentation of a picture ?) or
> should the TR be different from the event of interest ?
Do you mean whether the events should be synchronized with TR? If that is your question, the answer is no: Events don't have to align with your TR. Both options of -tstim in waver and -stim_times can handle such a situation.
Gang