Hello,
Basically, on a group 3dttest I am getting a significant activation outside the MNI brain template.
For each subject I smooth the data (4mm), run the GLM, take the results and smooth again (5mm, to prepare for group analysis), normalize each subject's data to MNI space using each subject's anatomical (3dAllineate), and then run 3dttest.
When I look at the group results on an MNI template the most significant area is a cluster that is about 70% outside of the MNI brain and 30% in the MNI brain. I believe that this area is real because it is so large, survives at a high statistical threshold, and no other clusters survive at this threshold. However, is there anything I can do to try and get this to appear more within the MNI template? Maybe a non-linear normalization? Any help would be greatly appreciated!
Thanks,
David