> So your model is the following?
> Connectivity = a0 + b1 * A + b2 * B + b3 * A * B + e
Yes, this is my model.
> By "connectivity with my ROIs of interest" do you mean that you have run multiple analyses each of which corresponds to one ROI
> as a seed?
Yes, I've completed two whole-brain connectivity analyses with bilateral hippocampi as seeds.
> 3dttest++, 3dMEMA, and 3dANOVA all can handle multiple groups, but 3dANOVA is the easiest one.
Great, thank you!