Thanks Rick!

0) The means are not really that different. I just gave an example.

Quote
Rick
Note that the mean applied to each modulator actually affects
the beta of the mean response, rather than the beta of the
modulated on.

1) Can you re-center across Conditions in a "normal" un-modulated analysis approach (e.g. stim times)?

2) We previously established that the mean response from the modulated apprach gives exactly the same betas/results as the normal non-modulated stim times apprach. I.e. Condition A vs Condition B (stim times) would be the same for Condition vs Condiiton B (mean response from AM2). If A and B (mean response from AM2) were re-centred this would no longer be true? SInce you say a re-centering woud affect the betas of Cond A and Cond B (mean response). When would this be a good idea?

3) Since you can compare Cond A and Cond B with the classic stim times approach, why would you want to re-center? And why with AM2 since the modulated regressors are not affected by it?

Yes, quite messy! But thanks a lot!