Well with the data we have collected we are primarily interested in group differences in grey matter based activations. So ultimately we are trying to eliminate unnecessary voxels, such as those from white matter, from our analyses to reduce the number of statistical tests (we have nearly 290,000 total voxels) AFNI performs during group analysis. Some preliminary group analyses that have been ran have shown nice results with respect to the p-value but maintains a high q-value. I know there are a number of ways to go about alleviating this issue but this seemed like a reasonable avenue for beginning to solve this problem. Perhaps you have some advice for alternative or more proper methods to help with this issue.
Thanks very much,
Austin