AFNI Message Board

Dear AFNI users-

We are very pleased to announce that the new AFNI Message Board framework is up! Please join us at:

https://discuss.afni.nimh.nih.gov

Existing user accounts have been migrated, so returning users can login by requesting a password reset. New users can create accounts, as well, through a standard account creation process. Please note that these setup emails might initially go to spam folders (esp. for NIH users!), so please check those locations in the beginning.

The current Message Board discussion threads have been migrated to the new framework. The current Message Board will remain visible, but read-only, for a little while.

Sincerely, AFNI HQ

History of AFNI updates  

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cdm
May 14, 2009 09:14AM
If I run a group-level analysis (e.g., 3dANOVA) on a subject-wise statistic (e.g., a pair of betas), which I assume are independent identically distributed normal random variables, should I ever expect to see fewer than 5% of the voxels exceeding the p < .05 threshold?

I'm using the Kriegeskorte method of passing a sphere through the brain, looking at the correlation between a local area and a psychological dissimilarity matrix, and then assigning the correlation coefficient to the center voxel. I was hoping to then just pass those statistics back out to AFNI, and let 3dANOVA do the group-level analysis. I get beautiful, noise-free brain maps at ridiculously low t values (e.g., t=1), but none of the t values exceed t=3. Doing some investigating, I've found that only 2% of my voxels exceed what AFNI thinks should be the .05 level.

Am I right that under either the null or alternative hypothesis, this should not happen (for large N, such as 60,000 voxels)? This must mean that I have violated the assumptions of the ANOVA, correct?

Is there any way to correct the p values? I'd like to use AlphaSim or 3dFDR to determine whether these clusters are significant, but the abnormally low t-values make this difficult. If 2% of my voxels exceed a given threshold, can I use that value as the p-threshold in AlphaSim to determine the cluster size threshold? Intuitively, if 2% of my voxels exceed a particular threshold, isn't 2% the upper limit my "true" p-value?

Thanks for the stats help,
cdm
Subject Author Posted

2% of voxels reaching p < .05

cdm May 14, 2009 09:14AM

Re: 2% of voxels reaching p < .05

Gang Chen May 14, 2009 05:44PM

Re: 2% of voxels reaching p < .05

rick reynolds May 14, 2009 06:26PM

Re: 2% of voxels reaching p < .05

cdm May 19, 2009 09:04AM

Re: 2% of voxels reaching p < .05

rick reynolds May 19, 2009 10:12AM

Re: 2% of voxels reaching p < .05

cdm May 20, 2009 11:04AM

Re: 2% of voxels reaching p < .05

Bob Cox May 15, 2009 09:14AM

Re: 2% of voxels reaching p < .05

cdm May 15, 2009 09:32AM