Hi Oori,
I'm not sure what the benefit might be for scaling based on the noise.
Maybe you are seeing something that I am not.
As I see it, the main goal in scaling is to make the magnitudes of BOLD
fluctuations comparable across both space and subjects. I want a beta
weight of 2 to mean the same thing across different parts of the brain,
as well as across subjects.
If a subject were scanned on a device that has fantastic TSNR, should
it make their BOLD responses twice as big? No, it should only make the
evaluation of the BOLD magnitude more reliable because of less variance
in the signal.
- rick