AFNI Message Board

Dear AFNI users-

We are very pleased to announce that the new AFNI Message Board framework is up! Please join us at:

https://discuss.afni.nimh.nih.gov

Existing user accounts have been migrated, so returning users can login by requesting a password reset. New users can create accounts, as well, through a standard account creation process. Please note that these setup emails might initially go to spam folders (esp. for NIH users!), so please check those locations in the beginning.

The current Message Board discussion threads have been migrated to the new framework. The current Message Board will remain visible, but read-only, for a little while.

Sincerely, AFNI HQ

History of AFNI updates  

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February 14, 2019 09:48AM
Hi, Robin-

Re. your Q2--
You can choose your desired "alpha" values in 3dClustSim with this option:
-athr a1 .. an = list of corrected (whole volume) alpha-values at which
                  the simulation will print out the cluster size
                  thresholds.  For each 'p' and 'a', the smallest cluster
                  size C(p,a) for which the probability of the 'p'-thresholded
                  image having a noise-only cluster of size C is less than 'a'
                  is the output (cf. the sample output, below)
                  [default = 0.10 0.05 0.02 0.01]

Re. your Q1--
You have cited the Big 3 of sources for clustering/thresholding stuff in AFNI to date. There has been a bit more work on ETAC by Bob, but the main point of it is included in his slides quite nicely.

Note that another REALLY relevant issue that a surprising number of published papers still do not get correct is that of what sidedness of testing to use. Using a pair of one-sided t-tests without correction doubles the FPR of reported results (and actually, does that while using a doubled p-value, which might even cause further FPR inflation). This is a model- and simulation-free result-- it is purely a mathematical point. As much as you strive to have a 'valid' p-value threshold, please also use correct testing for your hypotheses:
[www.ncbi.nlm.nih.gov] (HBM)
[www.biorxiv.org] (bioRxiv)

Re. your Q3--
Well, I'm not sure if there is a question there, or what the precise question is.

--pt
Subject Author Posted

AFNI and the pursuit of significant findings

Robin February 08, 2019 03:16AM

Re: AFNI and the pursuit of significant findings

gang February 08, 2019 12:55PM

Re: AFNI and the pursuit of significant findings

Robin February 12, 2019 12:30PM

Re: AFNI and the pursuit of significant findings

gang February 13, 2019 03:00PM

Re: AFNI and the pursuit of significant findings

Robin February 14, 2019 03:53AM

Re: AFNI and the pursuit of significant findings

ptaylor February 14, 2019 09:48AM

Re: AFNI and the pursuit of significant findings

Robin February 14, 2019 12:53PM

Re: AFNI and the pursuit of significant findings

gang February 14, 2019 01:59PM

Re: AFNI and the pursuit of significant findings

Robin February 14, 2019 02:40PM