1) You should be able to delete the brain+acpc.BRIK and brain+tlrc.BRIK files and still be able to view them. The 2D images in +acpc and +tlrc coordinates will be "warped-on-demand" from the brain+orig.BRIK file, using the transformation ("warp") stored in the brain+acpc.HEAD and brain+tlrc.HEAD files. However, you won't be able to volume render the brain+tlrc dataset, since that doesn't work with warp-on-demand.
2) You can also save disk space while keeping the .BRIK files by compressing them. A command like
gzip -9v brain+*c.BRIK
will compress the brain+acpc.BRIK and brain+tlrc.BRIK files. AFNI programs will still be able to read them (they will get the ".gz" suffix appended by the gzip program).
My personal preference would be to delete the brain+acpc.BRIK file and to compress the brain+tlrc.BRIK file. But this depends on what you want to do with them. Even if you delete them, you can alway re-create them using adwarp or using the "Write Anat" button (on the "Define Datamode" control panel).
bob cox