Hi, Fabian-

Great, glad that all worked well.

I think the cropping helps a lot with reducing the parameter space within which the computational algorithms check for alignment. It certainly also reduces memory load, and dataset sizes.

Recentering the dset to have reasonable coordinates also helps a lot: sometimes the hardest part of alignment is the first step.

And using the NMT v2 certainly makes sense, particularly with the CHARM atlas available there (as well as the D99). And using the 0.5mm version certainly makes sense in lots of applications as a reasonable voxel size-- if you ever want the higher res, there you will have it, too.

--pt